首页> 外文期刊>Journal of Virology >Size of the intracellular circular Epstein-Barr virus DNA molecules in infectious mononucleosis-derived human lymphoid cell lines.
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Size of the intracellular circular Epstein-Barr virus DNA molecules in infectious mononucleosis-derived human lymphoid cell lines.

机译:细胞内圆形Epstein-BART病毒DNA分子在传染性单核细胞增多症衍生的人淋巴细胞系中的大小。

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The size of non-integrated circular Epstein-Barr virus (EBV) DNA molecules isolated from seven different human lymphoblastoid cell lines of infectious mononucleosis origin has been determined by sedimentation analysis and by direct contour length measurements on electron micrographs. Six lines had intracellular circular EBV genomes of the same size as linear virion DNA molecules. The seventh line, established with the B95-8 strain of EBV, was the only one found to have circular EBV DNA molecules significantly smaller than virion DNA. The data show that intracellular EBV DNA circles of reduced size do not generally occur in infectious mononucleosis-derived cell lines.
机译:通过沉积分析和电子显微照片上的直接轮廓长度测量,确定了从七种不同人淋巴细胞分离的非整合循环的血管内分离的大小分子(EBV)DNA分子的大小已经确定。六条线具有与线性病毒乙酸DNA分子相同的细胞内圆形EBV基因组。与EBV的B95-8菌株建立的第七线是唯一一个发现具有明显小于病毒虫DNA的圆形EBV DNA分子的唯一。数据显示,在传染性单核细胞增多细胞增生的细胞系中通常不会发生细胞内EBV DNA圆圈。

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