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首页> 外文期刊>Journal of Virology >Circular Epstein-Barr virus genomes of reduced size in a human lymphoid cell line of infectious mononucleosis origin.
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Circular Epstein-Barr virus genomes of reduced size in a human lymphoid cell line of infectious mononucleosis origin.

机译：传染性单核细胞增收的人淋巴细胞系中的圆形Epstein-BART病毒基因组减小。

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摘要

Circular Epstein-Barr virus (EBV) DNA molecules have been purified and characterized from a human lymphoid cell line derived from a case of heterophile antibody-positive, blood transfusion-induced infectious mononucleosis, 883L. The circular EBV DNA in three cell lines obtained by transformation of human umbilical cord blood leukocytes with a strain of EBV originally derived from 883L was also studied. As estimated from sedimentation velocity data and electron microscopy, the circular EBV DNA molecules are 10 to 15% smaller than either the circular EBV DNA previously found intracellularly in several other types of EBV-transformed cells or the linear EBV DNA present extracellularly in virus particles. In addition, the EBV-transformed cord blood cell lines studied here differed from other EBV-transformed cells in that integrated virus DNA sequences could not be detected.
机译：已经纯化了圆形的Epstein-BARR病毒（EBV）DNA分子，其特征在于衍生自异丙型抗体阳性，血液输血诱导的传染性单核酶，883L的人淋巴细胞系。还研究了由最初衍生的EBV菌株的人脐带血白细胞转化获得的三种细胞系中的圆形EBV DNA，最初来自883L的883L。从沉淀速度数据和电子显微镜估计，圆形EBV DNA分子比以前在几种其他类型的EBV转化的细胞中细胞内发现的圆形EBV DNA或在病毒颗粒中细胞内呈细胞外包围的圆形EBV DNA的10至15％。此外，这里研究的EBV转化的脐带血细胞系不同于其他EBV转化的细胞中，不能检测到综合病毒DNA序列。

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