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首页> 外文期刊>Infection and immunity >Suppression of In Vitro Antibody Response by Spleen Cells of Mice Infected with Friend-Associated Lymphatic Leukemia Virus
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Suppression of In Vitro Antibody Response by Spleen Cells of Mice Infected with Friend-Associated Lymphatic Leukemia Virus

机译：抑制与朋友相关淋巴性白血病病毒感染的小鼠脾细胞体外抗体反应

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The ability of spleen cells of mice infected with oncornaviruses to depress the in vitro antibody responsiveness of normal lymphoid cells was exploited in an attempt to clarify the role played by the lymphatic leukemia virus (LLV) component in the immunodepressive properties of the Friend leukemia complex. Spleen cells of mice infected with LLV or, for comparison, with the entire complex were added to cultures of sheep erythrocyte-primed uninfected spleen cells, and the antibody-forming cells produced by the latter, after antigen restimulation, were assayed. The addition within 2 days from culture initiation of low numbers of cells infected with either virus preparation suppressed all stages of the response affecting the production of both immunoglobulin M and immunoglobulin G antibody. The activity of infected cells resisted doses of ultraviolet radiation which inhibit cell multiplication but was abolished by disrupting the cells and was prevented by the presence of anti-LLV antibodies. The LLV-infected spleen cells responsible for suppression were not removed by treatments which selectively remove or kill macrophages and exhibited surface properties of B lymphocytes. These results were interpreted as indicating that the effect is due to virus (or viral products) released by B cells. The suppressing cells in the spleens of mice in the early days of Friend leukemia complex infection presented superimposable properties, supporting the concept that their activity is also due to the LLV they release in large quantities. However, in later stages of infection, the spleens of Friend leukemia complex-infected mice also contained non-B-suppressing cells possibly derived from the proliferation of nonlymphoid LLV-producing cells caused by the neoplastic process.
机译：患有OncornaViruses的小鼠脾细胞抑制正常淋巴细胞的体外抗体反应性的能力，试图阐明淋巴性白血病病毒（LLV）组分在朋友白血病综合体的免疫抑制性质中发挥的作用。将患有LLV感染的小鼠的脾细胞或与整个复合物一起加入绵羊红细胞灌注的未染色的脾细胞培养物中，并测定由后者产生的抗体形成细胞进行测定。从培养后2天内加入培养出用病毒制剂感染的低数量细胞抑制了影响免疫球蛋白M和免疫球蛋白G抗体的响应的所有阶段。感染细胞的活性抵抗紫外线辐射的剂量，该剂量抑制细胞倍增，但通过破坏细胞而被消除并通过抗LLV抗体的存在防止。不通过选择性地除去或杀死巨噬细胞的处理除去负责抑制的LLV感染的脾细胞，并表现出B淋巴细胞的表面性质。这些结果被解释为表明效果是由于B细胞释放的病毒（或病毒产品）。在朋友白血病冬季的小鼠脾脏中抑制细胞呈现叠加性质，支持它们的活动的概念也是由于它们以大量释放的LLV。然而，在感染的后期阶段，朋友白血病的脾脏综合感染的小鼠还含有非B抑制细胞，可能来自由肿瘤过程引起的非含糊LLV产生细胞的增殖。

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