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Effects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3',5'-monophosphate metabolism in rabbit ileum.

机译:yersinia Enterocolitica热稳定肠毒素对兔回肠离子转运和循环鸟苷3',5'-一磷酸盐代谢的影响。

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Strains of Yersinia enterocolitica produce a heat-stable enterotoxin which is positive in the suckling mouse bioassay. Partial purification by a procedure previously worked out for heat-stable Escherichia coli enterotoxin yielded a substance which increases particulate guanylate cyclase activity and short-circuit current and inhibits active Cl-absorption in rabbit ileal mucosa. These effects of Y. enterocolitica enterotoxin are similar to those of heat-stable E. coli enterotoxin, suggesting a common mechanism of action.
机译:Yersinia Enterocoolitica的菌株产生热稳定的肠毒素,在哺乳小鼠生物测定中是阳性的。通过先前用于热稳定的大肠杆菌肠毒素的方法的部分纯化产生了一种增加颗粒状胍基环化酶活性和短路电流的物质,并抑制兔ILEAL粘膜中的活性CLOBINATION。 Y.Enterocolitica肠毒素的这些效果类似于热稳定的大肠杆菌肠毒素的作用,表明了一种常见的作用机制。

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