首页> 外文期刊>The biochemical journal >Endocytosis of β-N-acetylglucosaminidase from sections of mucolipidosis-II and-III fibroblasts by non-parenchymal rat liver cells
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Endocytosis of β-N-acetylglucosaminidase from sections of mucolipidosis-II and-III fibroblasts by non-parenchymal rat liver cells

机译:非实质大鼠肝细胞从粘膜脂素-II和-III成纤维细胞切片中β-N-乙酰甘氨酸胺酶的内吞作用

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pbeta-N-Acetylglucosaminidase isolated from the secretions of fibroblasts of mucolipidosis-II and -III patients is internalized by cultured non-parenchymal rat liver cells. The rate of endocytosis compared with that of beta-N-acetylglucosaminidase from control fibroblasts was 11 and 19% for the enzyme from mucolipidosis-II and -III patients respectively. The inhibition of endocytosis by mannan indicates that the beta-N-acetylglucosaminidase from mucolipidosis-II and -III patients is recognized by cell-surface receptors specific for mannose./p
机译:β-乙酰戊酰胺酶中分离出的粘膜脂素病虫病-II和-III患者的成纤维细胞分泌物被培养的非实质大鼠肝细胞内化。与对照成纤维细胞的β-乙酰甘氨酸氨基氨基氨基氨基胺酶相比的内吞炎率分别为来自粘成纤维细胞的酶的11至19%,分别为粘液素菌病-II和-III患者的酶。甘露甘露植物的内吞作用的抑制表明,来自粘膜脂素菌病-II和-III患者的β-乙酰戊酰胺酶被甘露糖特异的细胞表面受体识别。

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