首页> 外文期刊>Journal of Virology >Cell surface expression of the env gene polyprotein of dual-tropic mink cell focus-forming murine leukemia virus.
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Cell surface expression of the env gene polyprotein of dual-tropic mink cell focus-forming murine leukemia virus.

机译:双回流貂细胞聚焦鼠白血病病毒env基因多蛋白的细胞表面表达。

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Differences have been observed in the kinetics of processing of the env gene polyprotein of ecotropic, xenotropic, and dual-tropic mink cell focus-forming (MCF) murine leukemia virus. In pulse-chase experiments, the env gene polyprotein of the dural-tropic MCF virus exhibits a marked increase in stability relative to that of either ecotropic or xenotropic virus. A comparison of cell surface expression of env gene products of ecotropic, xenotropic, and dual-tropic MCF murine leukemia virus has been made. Only gp70 is accessible to lactoperoxidase-catalyzed radioiodination of fibroblasts infected by ecotropic or xenotropic virus, whereas both gp70 and the env gene polyprotein are expressed on the surface of dual-tropic MCF virus-infected cells.
机译:在生态转养,异熵和双向水貂细胞聚焦(MCF)鼠白血病病毒的环境中,在加工过程中观察到差异。在脉冲呼应实验中,多云 - 热带MCF病毒的ENV基因多蛋白具有相对于生态学或异熵病毒的稳定性显着增加。生态学,异丙酚和双层鼠白血病病毒的Env基因产物细胞表面表达的比较。乳酰氧基酶催化的成纤维细胞催化仅GP70被生态学或异窦病毒感染的成纤维细胞的放射性碘,而GP70和ENV基因多蛋白均在双热带MCF病毒感染细胞的表面上表达。

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