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首页> 外文期刊>The biochemical journal >Importance of mammalian nuclear-envelope nucleoside triphosphatase in nucleo-cytoplasmic transport of ribonucleoproteins
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Importance of mammalian nuclear-envelope nucleoside triphosphatase in nucleo-cytoplasmic transport of ribonucleoproteins

机译：哺乳动物核包围核苷三磷酸酶在核糖核蛋白核核蛋白核核酸转运中的重要性

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pThe nucleoside triphosphate-stimulated efflux of RNA from isolated nuclei was studied under a range of conditions, and the effects of these conditions on the process were compared with the properties of the nucleoside triphosphatase located in the pore complex. A marked similarity between the rate of efflux and the rate of nucleoside triphosphate hydrolysis was apparent, in terms of substrate specificity, sensitivity to treatment with insolubilized trypsin, kinetics and the effects of increased ionic strength and of many inhibitors. These results are taken, in view of earlier evidence, to suggest that the activity of the nucleoside triphosphatase is a prerequisite for nucleo-cytoplasmic RNA transport in vivo. There are some indications that the nuclear-envelope lipid is also involved in regulating the efflux process./p
机译：在一系列条件下研究了来自分离核的RNA的核苷刺激的RNA的核苷酸的流出，并将这些条件对在孔隙络合物中的核苷三磷酸酶的性质进行比较。在底物特异性方面，流出率与核苷三磷酸三磷酸三磷酸三磷酸三磷酸水解率之间的明显相似性显而易见，敏感性胰蛋白酶，动力学和不同离子强度和许多抑制剂的影响。鉴于早期的证据，鉴于核苷三磷酶的活性是鉴于核苷酸三磷酸酶的活性是体内核 - 细胞质RNA转运的前提。有一些迹象表明核包膜脂质也参与调节流出过程。

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