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首页> 外文期刊>Journal of Virology >Association of endogenous retroviruses with radiation-induced leukemias of BALB/c mice.
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Association of endogenous retroviruses with radiation-induced leukemias of BALB/c mice.

机译：内源性逆转录病毒与辐射诱导的BALB / C小鼠白血病的关联。

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摘要

X-irradiation of BALB/c mice in the second month of life induced a high incidence of generalized lymphatic leukemia of T-cell origin, beginning at 7 months of age. Infectious ecotropic murine leukemia virus (B-tropic predominant over N-tropic) was isolable from all tumor extracts but exhibited a wide titer range among individual leukemias. Detection of infectious xenotropic virus usually required extensive amplification on indicator cells. Dual-tropic (mink cell focus-forming) virus has not been found in the leukemias. Expression of ecotropic virus in tail extracts prepared at 6.5 months of age, although greatly enhanced compared with unirradiated controls, was not found to be prognostic of tumor development in individual mice. We conclude that leukemogenesis does not show a simple dependence on infectious murine leukemia virus expression in these mice.
机译：生命的第二个月的Balb / C小鼠的X辐射诱导了T细胞源的广义淋巴性白血病的高发病率，从7个月开始。感染的生态鼠白血病病毒（B-Tropic over N-Tropic）可从所有肿瘤提取物中分离，但在单个白血病中表现出宽的滴度范围。传染性异胃病毒的检测通常需要对指示细胞进行广泛扩增。在白血病中未发现双回归（貂皮细胞聚焦）病毒。生态病毒在6.5个月的尾部提取物中的表达虽然与未经辐射的对照相比，虽然与未辐射的对照相比大大增强，但在单个小鼠中未被发现是肿瘤发育的预后。我们得出结论，白血病对这些小鼠中的感染鼠白血病病毒表达没有表现出简单的依赖性。

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