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首页> 外文期刊>Journal of Virology >Occurrence of temperature-sensitive influenza A viruses in nature.
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Occurrence of temperature-sensitive influenza A viruses in nature.

机译：在自然界中发生温度敏感的流感病毒。

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The origin and characteristics of the first naturally occurring temperature-sensitive (ts) strain of influenza A virus identified in 1973, Xia-ts, are described. Natural ts strains were found to occur in the early egg passage material of all influenza A subtypes examined, but the proportion of ts virus varied from 8.3% for old H1N1 virus (1949 to 1957) to 82.4% for recent H3N2 virus (1979 to 1980). A number of strains were found to be composed of a mixture of ts and wild-type (ts+) particles. Six natural ts strains with different shutoff temperatures and one ts+ strain of the H1N1 subtype were tested in antibody-free volunteers. Strains with a shutoff temperature of 38 degrees C or lower caused very mild symptoms, whereas those with a shutoff temperature of 39 degrees C and the ts+ strain were much more reactogenic. By complementation tests against a set of prototype WSN ts mutants with a defined genetic lesion, the ts lesion of two H3N2 viruses (HK/8/68 and Xia-ts) was located on the NP gene and that of two H1N1 viruses (Tianjin/78/77 and Beijing/1/79) was located on the M protein gene. The present study demonstrates the widespread occurrence in nature of influenza viruses of different degrees of temperature sensitivity and presumably of different degrees of virulence.
机译：描述了1973年，XIA-TS中鉴定的第一种天然存在的温敏感（TS）病毒的自然温度敏感（TS）菌株的起源和特征。发现天然TS菌株发生在所有流感的早期卵子通道材料中，但TS病毒的比例从最近的H1N1病毒（1949至1957年）的8.3％变化至82.4％（1979年至1980年） ）。发现许多菌株由TS和野生型（TS +）颗粒的混合物组成。在无抗体志愿者中测试具有不同截止温度和H1N1亚型的一个TS +菌株的六种天然TS菌株。截止温度为38℃或更低的菌株引起的症状非常轻微，而截止温度为39摄氏度和TS +菌株的那些再现。通过对具有定义遗传病变的一组原型WSN TS突变体的互补试验，两个H3N2病毒的TS病变（HK / 8/68和XIA-TS）位于NP基因上，两种H1N1病毒（天津/ 78/77和北京/ 1/79）位于M蛋白基因上。本研究表明，不同温度敏感度的流感病毒的本质上普遍发生，并且可能是不同程度的毒力。

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