Genetic studies on capsid-length determination in bacteriophage T4. I. Isolation and partial characterization of second-site revertants of a gene 23 mutation affecting capsid length.

D H Doherty

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Genetic studies on capsid-length determination in bacteriophage T4. I. Isolation and partial characterization of second-site revertants of a gene 23 mutation affecting capsid length.

机译：胶囊长度测定的遗传研究噬菌体T4。 I.影响衣壳长度的基因23突变的第二站点雷差分离和部分表征。

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The T4 mutation ptg19-80 affects the mechanism of capsid-length determination. It is located in gene 23, which encodes the major structural protein of the capsid. The mutation results in the production of abnormal-length capsids in high frequencies. This paper describes the isolation and partial characterization of second-site revertants of ptg19-80. In the course of their analysis, it was discovered that ptg19-80 is itself a double mutation consisting of a gene 23 mutation (ptg19-80c), which causes the morphogenetic defect, and a suppressor mutation located near the lysozyme gene. Phenotypic characterization of nine pseudo-wild-type revertants of this double-mutation revealed that these revertants all produced lower frequencies of abnormal capsids than did ptg19-80. Seven of these revertants were shown to contain two suppressor mutations, one mapping in or near gene 22 and done mapping in or near gene 24. Both mutations were required for suppression. These suppressors displayed no discernible phenotype in the absence of ptg19-80c.

机译：T4突变PTG19-80影响衣壳长度测定的机制。它位于基因23中，它们编码衣壳的主要结构蛋白。突变导致在高频下产生异常长度的衣壳。本文介绍了PTG19-80的第二站点雷差的隔离和部分表征。在分析过程中，发现PTG19-80本身是由基因23突变（PTG19-80C）组成的双突变，这导致了溶菌酶基因附近的形态发生缺陷和抑制突变。这种双突变的九种伪型恢复剂的表型表明显示出这些回复剂的所有产生的毛囊异常的频率低于PTG19-80。显示出七个这些回复剂含有两个抑制突变，在基因22中或接近基因22中的一个映射，并在基因24中进行映射。抑制所需的突变。这些抑制剂在没有PTG19-80C的情况下没有显示出可辨别的表型。

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《Journal of Virology》 |1982年第2期|共14页
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D H Doherty;
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1. Genetic studies on capsid-length determination in bacteriophage T4. I. Isolation and partial characterization of second-site revertants of a gene 23 mutation affecting capsid length. [J] . D H Doherty Journal of Virology . 1982,第2期

机译：胶囊长度测定的遗传研究噬菌体T4。 I.影响衣壳长度的基因23突变的第二站点雷差分离和部分表征。
2. Genetic studies on capsid-length determination in bacteriophage T4. I. Isolation and partial characterization of second-site revertants of a gene 23 mutation affecting capsid length. [J] . D H Doherty Journal of Virology . 1982,第2期

机译：胶囊长度测定的遗传研究噬菌体T4。 I.影响衣壳长度的基因23突变的第二站点雷差分离和部分表征。
3. Genetic studies on capsid-length determination in bacteriophage T4. II. Genetic evidence that specific protein-protein interactions are involved. [J] . D H Doherty Journal of Virology . 1982,第2期

机译：胶囊长度测定的遗传研究噬菌体T4。 II。涉及特定蛋白质 - 蛋白质相互作用的遗传证据。
4. Scaffold-mediated size determination of bacteriophage capsids by mobile genetic elements [D] . Dearborn, Altaira D. 2012

机译：支架遗传介导的可移动遗传元件确定噬菌体衣壳的大小
5. Genetic studies on capsid-length determination in bacteriophage T4. I. Isolation and partial characterization of second-site revertants of a gene 23 mutation affecting capsid length. [O] . D H Doherty 1982

机译：T4噬菌体衣壳长度测定的遗传研究。 I.影响衣壳长度的基因23突变的第二位点回复子的分离和部分表征。
6. Function of gene 49 of bacteriophage T4. I. Isolation and biochemical characterization of very fast-sedimenting DNA. [O] . B Kemper, E Janz 1976

机译：噬菌体T4基因49的功能。 I.非常快速沉积DNA的分离和生化特征。
7. Cooperative Effects of Bacterial Mutations Affecting lambda N Gene Expression. I. Isolation and Characterization of a 'nus'B Mutant. [R] . Friedman, D. I., Baumann, M., Baron, L. S. 1976

机译：影响λN基因表达的细菌突变的协同作用。 I.'nus'B突变体的分离和表征。

Genetic studies on capsid-length determination in bacteriophage T4. I. Isolation and partial characterization of second-site revertants of a gene 23 mutation affecting capsid length.

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