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首页> 外文期刊>Journal of Virology >Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen.
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Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen.

机译:具有针对Simian病毒40 T-抗原的单克隆抗体反应的细胞蛋白。

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Several recently isolated monoclonal antibodies which reacted with simian virus 40 T antigens also reacted with proteins found in uninfected and untransformed cells. The proteins were different from each other, PAb419 reacting with a 35,000-molecular-weight protein, PAb427 reacting with a 75,000-molecular-weight phosphoprotein, PAb405 reacting with a 150,000-molecular-weight phosphoprotein, and PAb204 reacting with a 68,000-molecular-weight protein. It is suggested that although some of these cross-reactions may be fortuitous, they may, as an alternative, reflect similarities of shape and perhaps function between domains of the viral T antigen and the relevant host proteins.
机译:与Simian病毒40 T抗原反应的几种最近分离的单克隆抗体也与在未传染和未转化的细胞中发现的蛋白质反应。蛋白质彼此不同,PAB419与35,000分子量的蛋白质反应,PAB427与75,000分子量的磷蛋白反应,与150,000分子量磷蛋白反应,与68,000分子反应的PAB204反应重量蛋白。建议,尽管这些交叉反应中的一些可能是偶然的,但它们可以作为替代,反映形状的相似性,并且可能在病毒T抗原结构域和相关宿主蛋白之间的函数。

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