首页> 外文期刊>Journal of Virology >In vitro secondary generation of cytotoxic T lymphocytes in mice with mumps virus and their mumps-specific cytotoxicity among paramyxoviruses.
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In vitro secondary generation of cytotoxic T lymphocytes in mice with mumps virus and their mumps-specific cytotoxicity among paramyxoviruses.

机译:用腮腺炎病毒的小鼠细胞毒性T淋巴细胞的体外次生次生次生次生次生二代小鼠及其副曲目中的腮腺炎特异性细胞毒性。

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Murine cells (L929, MC57G, and P815 mastocytoma) defectively infected with the egg-adapted vaccine strain of mumps virus were found to be susceptible to cytotoxic T-lymphocyte (CTL)-mediated lysis. In vitro secondary, but not in vivo primary, generated CTL caused cytolysis of these targets in an H-2-restricted manner. UV-inactivated-mumps virus-coated murine cells were also found to be susceptible to CTL-mediated lysis. Comparisons of murine CTL-mediated lysis by three paramyxoviruses (mumps, Sendai, and Newcastle disease viruses) indicated that no cross-reactivity occurred. The CTL response with mumps virus exhibited specific unresponsiveness patterns, as influenced by the H-2 K/D regions of the mouse strains, that were partially different from those of Sendai virus and Newcastle disease virus.
机译:发现鼠细胞(L929,MC57G和P815乳腺细胞瘤)发现患有鸡蛋适应的腮腺炎病毒疫苗病毒的疫苗菌株敏感,易于细胞毒性T淋巴细胞(CTL)介导的裂解。体外次级,但不在体内初级,产生的CTL以H-2限制的方式引起这些靶标的细胞分解。还发现UV灭活 - 腮腺炎病毒涂覆的鼠细胞易于CTL介导的裂解。鼠CTL介导的三个副副病毒(腮腺炎,仙台和新宫疾病病毒)的比较表明不会发生交叉反应性。具有腮腺炎病毒的CTL响应表现出特定的无响应模式,其受小鼠菌株的H-2 K / D区域的影响,其部分地与仙台病毒和新城疫病毒的影响。

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