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首页> 外文期刊>Nucleic acids research >Ultraviolet-induced 8,8-adenine dehydrodimers in oligo- and polynucleotides
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Ultraviolet-induced 8,8-adenine dehydrodimers in oligo- and polynucleotides

机译：紫外线诱导的寡核苷酸和多核苷酸的8,8-腺嘌呤脱氢剂

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摘要

Characteristic fluorescence excitation and emission is induced by either acetone-sensitized 313 nm irradiation of mixtures of 8-bromoadenoslne and adenosine or 254 nm irradiation of oligo- and polynucleotides containing adenine neighbors. The acetone-sensitized reaction involves cleavage of bromine from 8-bromoadenosine with activation of C-8, leading to formation of an 8,8-adenosine dehydrodimer. Comparable fluorescence properties arise in the unsensitized photoreaction of dApdA, pdApdA, ApA, poly(dA), poly(A), poly(dA-dT), and poly(dA.U). The previously unidentified adenine ultraviolet photoproduct described by Porschke has been isolated as several variants from solutions of pdApdA and poly(dA) irradiated at 254 nm. Based upon fluorescence spectra and mass spectra, these variants are shown to contain the 8,8-adenine dehydrodimer moiety.
机译：通过丙酮敏化的313nm照射的8-溴罗纳洛尼和腺苷的混合物或含有腺嘌呤和多核苷酸的254nm照射的丙酮敏化的313nm照射诱导特征荧光激发和发射。丙酮敏化反应涉及从8-溴纳米的溴化溴的激活，导致形成8,8-腺苷脱氢剂。在DAPDA，PDAPDA，APA，聚（DA），聚（A），聚（DA-DT）和聚（DA.U）的不陈旧性光熔剂中出现相当的荧光性能。通过Porschke描述的先前未识别的腺嘌呤紫外线光调节已被隔离为从PDAPDA的溶液和照射在254nm处的Poly（DA）的溶液的几种变体。基于荧光光谱和质谱，这些变体被示出含有8,8-腺嘌呤脱硫部分。

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