Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2.

E A Cohen; P Gaudreau; P Brazeau; Y Langelier

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Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2.

机译：通过针对亚基H2的寡肽诱导的抗血清中和疱疹病毒核糖核苷酸还原酶活性的中和。

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Herpes simplex virus type 1 ribonucleotide reductase is associated with two polypeptides of apparent molecular weights 136,000 and 38,000. The two polypeptides form a tight complex and, therefore, are often coprecipitated by monoclonal antibodies. We report here that immunoglobulins G purified from polyclonal rabbit antisera (P9) raised against a nonapeptide corresponding to the carboxy terminus of the 38,000-dalton polypeptide specifically neutralize the herpes simplex virus ribonucleotide reductase activity. We suggest that the P9 immunoglobulin G neutralizes the reductase activity by impairing the association of the two subunits (H1 and H2) of the enzyme.

机译：单纯疱疹病毒类型1核糖核苷酸还原酶与表观分子量136,000和38,000的两种多肽有关。两种多肽形成紧密复合物，因此通常通过单克隆抗体共沉淀。在此报告，从多克隆兔抗血清（P9）纯化的免疫球蛋白G升高对应于38,000-dalton多肽的羧基末端的非肽，特别是中和疱疹病毒核糖核糖核苷酸还原酶活性。我们表明P9免疫球蛋白G通过损害酶的两个亚基（H1和H2）的关联来中和还原酶活性。

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《Journal of Virology》 |1986年第3期|共4页
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E A Cohen; P Gaudreau; P Brazeau; Y Langelier;
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收录信息美国《科学引文索引》(SCI);
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1. Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2. [J] . E A Cohen, P Gaudreau, P Brazeau, Journal of Virology . 1986,第3期

机译：通过针对亚基H2的寡肽诱导的抗血清中和疱疹病毒核糖核苷酸还原酶活性的中和。
2. Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2. [J] . E A Cohen, P Gaudreau, P Brazeau, Journal of Virology . 1986,第3期

机译：通过针对亚基H2的寡肽诱导的抗血清中和疱疹病毒核糖核苷酸还原酶活性的中和。
3. Characterization of heterosubunit complexes formed by the R1 and R2 subunits of herpes simplex virus 1 and equine herpes virus 4 ribonucleotide reductase [J] . Joe CONNER, Yunming SUN The biochemical journal . 2000,第1期

机译：单纯疱疹病毒1的R1和R2亚基形成的异源轴复合物的表征和马疱疹病毒4核糖核苷酸还原酶
4. Analysis of synonymous codon usage on the small subunit of ribonucleotide reductase gene from duck plague virus [C] . Wei Min, Cheng Anchun, Wang Mingshu, BMEI 2012;International Conference on Biomedical Engineering and Informatics . 2012

机译：鸭瘟病毒核糖核苷酸还原酶基因小亚基同义密码子选择分析
5. Processivity of the herpes simplex virus DNA polymerase: Role of high-affinity DNA binding by the processivity subunit. [D] . Randell, John Cranston Wall. 2003

机译：单纯疱疹病毒DNA聚合酶的合成能力：通过合成亚基高亲和力DNA结合的作用。
6. Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2. [O] . E A Cohen, P Gaudreau, P Brazeau, 1986

机译：寡肽诱导的针对H2亚基的抗血清对单纯疱疹病毒核糖核苷酸还原酶活性的中和作用。
7. Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2 [O] . E A Cohen, P Gaudreau, P Brazeau, 1986

机译：通过针对亚基H2的寡肽诱导的抗血清中和疱疹病毒核糖核糖核苷酸还原酶活性的中和

Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2.

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