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首页> 外文期刊>Journal of Virology >Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection.
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Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection.

机译：人免疫缺陷病毒感染中特异细胞介导的免疫应答的特征。

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The human immunodeficiency virus (HIV)-specific lymphocyte proliferation response was determined for 40 persons at different stages of HIV infection. The specific response to purified HIV virion antigens from strain HTLV-IIIB was poor, occurred in only 9 of the 40 subjects, was not improved with the addition of interleukin-2, and was more frequent in symptom-free individuals (46%) than in patients with lymphadenopathy syndrome (10%). Reactivity to subcomponent p24 was better than that to whole HIV; reactivity was present in five of six infected persons and increased with the addition of exogenous interleukin-2. Reactivities to subcomponents (g)p41 and gp120 were also measured. This is the first evidence of a specific cell-mediated immune response to HIV antigen in HIV-infected persons. Monkeys immunized with purified HIV or with purified p24 displayed cellular immunoreactivity both to whole HIV and to subcomponents. In contrast to the poor reactivity to HIV antigen, the lymphocytes of the patients had good specific cell proliferation responses to cytomegalovirus and herpes simplex virus challenge and a normal response to the addition of phytohemagglutinin. The results suggest a functional defect in peripheral lymphocytes of some HIV-infected individuals on the basis of their response to whole HIV antigen and a better response to gag protein.
机译：在不同阶段的艾滋病毒感染阶段测定人类免疫缺陷病毒（HIV）特异性淋巴细胞增殖反应。对来自菌株HTLV-IIIB的纯化HIV病毒藻抗原的特异性反应差，仅在40个受试者中的9个中发生，随着白细胞介素-2的添加而没有改善，并且在无症状的个体中更频繁地频繁（46％）淋巴结病综合征患者（10％）。对子组件P24的反应性比整个艾滋病毒更好;反应性存在于六种感染者中的5个中，并随着外源间白细胞介素-2增加而增加。还测量了对子组件（G）P41和GP120的反应性。这是对艾滋病毒感染者HIV抗原的特定细胞介导的免疫应答的第一种证据。用纯化的HIV或用纯化的P24免疫的猴子，均显示细胞免疫反应，均为整个HIV和子组件。与对HIV抗原的不良反应性相比，患者的淋巴细胞对细胞瘤病毒的良好特异性细胞增殖反应和单纯疱疹病毒攻击以及对添加植物葡萄糖素的正常反应。结果表明，在对整个HIV抗原的反应和对GAG蛋白的反应的基础上，一些艾滋病毒感染个体的外​​周淋巴细胞功能缺陷。

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