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首页> 外文期刊>Journal of Virology >Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells.
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Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells.

机译：持续性病毒感染的有效许可需要在病毒特异性Lyt2 + T细胞和非特异性骨髓衍生细胞之间的合作。

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The lifelong chronic lymphocytic choriomeningitis virus (LCMV) infection established in neonatally or congenitally infected mice can be eliminated by adoptive transfer of lymphoid cells from LCMV-immune mice. In this study, we have identified the effector cells mediating the clearance of persistent and disseminated LCMV infection. Using mice that are recombinant in the H-2 region and by selective depletion of lymphocyte subpopulations, we show that viral clearance was mediated by LCMV-specific Lyt2+ L3T4- T cells that are restricted to the class I genes of the major histocompatibility complex. In addition, our results show a requirement for host-derived bone marrow cells for the effective elimination of virus from the liver. These studies emphasize the importance of virus-specific T cells and an intact bone marrow function in viral clearance.
机译：通过从LCMV-IMMVUNE小鼠的淋巴细胞通过淋巴细胞通过淋巴细胞通过淋巴细胞的血液转移，可以消除在新生儿或初始感染的小鼠中建立的终身慢性淋巴细胞核炎病毒（LCMV）感染。在这项研究中，我们鉴定了介导持续和播散的LCMV感染的间隙的效应细胞。使用在H-2区域中重组的小鼠并通过选择性耗竭淋巴细胞亚群，我们表明病毒间隙由LCMV特异性Lyt2 + L3T4-T细胞介导，所述细胞仅限于主要组织相容性复合物的I类基因。此外，我们的结果表明，宿主源性骨髓细胞的要求，用于从肝脏中有效地消除病毒。这些研究强调了病毒特异性T细胞的重要性和病毒间隙中的完整骨髓功能。

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