The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.

G Calothy; D Laugier; F R Cross; R Jove; T Hanafusa; H Hanafusa

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The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.

机译：膜结合结构域和P60V-SRC的肌肌肌肌瘤不适合刺激细胞增殖必不可少。

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Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation and anchorage independence. Analysis of src delection mutants revealed that the amino-terminal one-third of p60v-src, including the membrane-binding domain, is not essential for induction of cell proliferation. These results demonstrated that, in contrast to the cellular target(s) involved in morphological transformation and anchorage independence, the target(s) involved in mitogenic activity is accessible to nonmyristylated src proteins.

机译：以前的研究表明，形态转化和锚固独立需要涉及蛋白质化和蛋白质膜结合的Rous Sarcoma病毒P60V-SRC的氨基末端域。 SRC薄解突变体的分析显示，氨基末端三分之一的P60V-SRC，包括膜结合结构域，对诱导细胞增殖不是必要的。这些结果表明，与涉及形态转化和锚固独立性的细胞靶标的相反，涉及促丝膜活性的靶标可用于非亚赖酰基化的SRC蛋白。

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《Journal of Virology》 |1987年第5期|共4页
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G Calothy; D Laugier; F R Cross; R Jove; T Hanafusa; H Hanafusa;
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收录信息美国《科学引文索引》(SCI);
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1. The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation. [J] . G Calothy, D Laugier, F R Cross, Journal of Virology . 1987,第5期

机译：膜结合结构域和P60V-SRC的肌肌肌肌瘤不适合刺激细胞增殖必不可少。
2. The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation. [J] . G Calothy, D Laugier, F R Cross, Journal of Virology . 1987,第5期

机译：膜结合结构域和P60V-SRC的肌肌肌肌瘤不适合刺激细胞增殖必不可少。
3. Stimulation of bumetanide-sensitive Na+/K+/Cl- cotransport by different mitogens in synchronized human skin fibroblasts is essential for cell proliferation. [J] . R Panet, H Atlan Journal of cell biology . 1991,第2期

机译：在同步的人皮肤成纤维细胞中，不同丝裂原刺激布美他尼敏感的Na + / K + / Cl-共转运对细胞增殖至关重要。
4. Microfluidic system for monitoring of cardiac (H9C2) cell proliferation. [C] . A. Kobuszewska, P. Cwik, E. Jastrzebska, Bio-MEMS and medical microdevices III . 2017

机译：用于监测心脏（H9C2）细胞增殖的微流体系统。
5. Essential PcsB chap domain protein interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae. [D] . Sham, Chris Lok-To. 2012

机译：必需的PcsB chap域蛋白与肺炎链球菌中的必需FtsXSpn细胞分裂蛋白相互作用。
6. The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation. [O] . G Calothy, D Laugier, F R Cross, 1987

机译：p60v-src的膜结合结构域和肉豆蔻酰化对于刺激细胞增殖不是必需的。
7. The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation [O] . G Calothy, D Laugier, F R Cross, 1987

机译：P60V-SRC的膜结合结构域和MyRistylation对细胞增殖的刺激不是必需的

The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.

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