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Biopharmaceutics & Drug Disposition

中文名称：生物制药与药物处置

ISSN：1099-081X
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1.Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in anemic cancer patients

机译：贫血患者促红细胞生成素随时间变化的非线性混合效应建模
- 作者：Sihem Ait-Oudhia;An Vermeulen;Wojciech Krzyzanski
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第1期
2.The membrane transport of flavonoids from Crossostephium chinense across the Caco-2 monolayer

机译：横贯十字花科植物中黄酮类化合物跨Caco-2单层的膜运输
- 作者：Ying Wang;Qi Wu;Xiu-Wei Yang;Xiaoda Yang;Kui Wang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第1期
- flavonoids;
- selagin;
- Caco-2;
- efflux;
- MRP;
3.Mechanistic population modeling of diabetes disease progression in Goto-Kakizaki rat muscle

机译：后藤崎崎大鼠肌肉中糖尿病疾病进展的机械种群建模
- 作者：Jing Nie;Debra C. DuBois;William J. Jusko;Richard R. Almon
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第1期
- population model;
- type 2 diabetes;
- disease progression;
- PDK4;
- Goto-Kakizaki rats;
4.Preclinical pharmacokinetics and metabolism of MNP001, a piperidine analog of 3-carbamyl compounds

机译：3-氨基甲酰基化合物的哌啶类似物MNP001的临床前药代动力学和代谢
- 作者：Binfeng Xia;Desuo Wang;Laura M. Fox
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第1期
- MNP001;
- pharmacokinetics;
- bioavailability;
- metabolism;
- plasma protein binding;
5.Pharmacokinetics of mirodenafil and Its two metabolites, SK3541 and SK3544, in spontaneously or DOCA–salt-induced hypertensive rats

机译：美罗那非及其两种代谢物SK3541和SK3544在自发或DOCA盐诱导的高血压大鼠中的药代动力学
- 作者：Young S. Lee;Young H. Choi;In S. Yoon;Tae K. Kim;Keun H. Ryu;Bong-Y. Lee;Myung G. Lee
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第1期
- mirodenafil;
- pharmacokinetics;
- SHRs;
- DOCA–salt rats;
- hypertension;
6.Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition

机译：饮食癌化学预防性化合物二苯甲酰甲烷在大鼠体内的药代动力学以及纳米乳和Nrf2基因敲除对其处置的影响
- 作者：Wen Lin;Jin-Liern Hong;Guoxiang Shen;Rachel T. Wu;Yuwen Wang;Mou-Tuan Huang;Harold L. Newmark;Qingrong Huang;Tin Oo Khor;Tycho Heimbach;Ah-Ng Kong
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第2期
- dibenzoylmethane;
- nanotechnology-based drug delivery system;
- Nrf2 genotype;
7.Effects of formulation and route of administration on the systemic availability of Ex-RAD?, a new radioprotectant, in preclinical species

机译：制剂和给药途径对临床前物种Ex-RAD ？（一种新型的辐射防护剂）的系统有效性的影响
- 作者：Amy W. Chun;Robert E. Freshwater;David R. Taft;Amanda M. Gillum;Manoj Maniar
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第2期
- Ex-RAD?;
- systemic availability;
- preclinical species;
- metabolic stability;
- radioprotectant;
8.1,25-Dihydroxyvitamin D₃ on intestinal transporter function: studies with the rat everted intestinal sac

机译：1,25-二羟基维生素D _{3 对肠道转运蛋白的作用：大鼠翻肠肠囊的研究}
- 作者：Han-Joo Maeng Matthew R. Durk Edwin C. Y. Chow Ragia Ghoneim K. Sandy Pang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第2期
9.Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats

机译：肝纤维化不影响5-氟尿嘧啶在大鼠中的药代动力学
- 作者：Masashi Nagata;Yumi Hidaka;Kinta Hatakeyama;Yohei Kawano;Tomomi Iwakiri;Manabu Okumura;Kazuhiko Arimori
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第2期
- 5-fluorouracil;
- hepatic fibrosis;
- pharmacokinetics;
- intravenous injection;
- intrahepatic arterial injection;
10.Compliance descriptors: Analysis and evaluation in terms of therapeutic effect?

机译：依从性描述词：就治疗效果进行分析和评估？
- 作者：Sarem Sarem;Jun Li;Fahima Nekka
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第2期
- compliance parameters;
- therapeutic impact;
- modeling and simulation;
- Markov chain;
11.Pharmacokinetics of a combination of Δ9-Tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock

机译：Δ 9 -四氢大麻酚和塞来昔布在猪失血性休克模型中的药代动力学
- 作者：Pavan K. Vaddady Nitin Mehrotra Xiaofeng Zhang Charles R. Yates Bob M. Moore Bernd Meibohm
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第2期
- tetrahydro-cannabinol;
- celecoxib;
- hemorrhagic shock;
- pharmacokinetics;
12.Intestinal transport of bis(12)-hupyridone in Caco-2 cells and its improved permeability by the surfactant Brij-35

机译：双（12）-庚啶酮在Caco-2细胞中的肠运输及其表面活性剂Brij-35的通透性改善
- 作者：Hua Yu;Yue Qing Hu;Fanny C. F. Ip;Zhong Zuo;Yi Fan Han;Nancy Y. Ip
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第3期
- bis(12)-hupyridone;
- absorption;
- P-glycoprotein;
- multidrug resistance-associated protein;
- nonionic surfactant;
13.Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug–drug interactions

机译：酮康唑和利福平对OAT1和OATP1B1转运活性的抑制作用：对药物相互作用的考虑
- 作者：Min-Koo Choi;Qing-Ri Jin;Yeong-Lim Choi;Sung-Hoon Ahn;Myung-Ae Bae;Im-Sook Song
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第3期
- transporter-mediated drug–drug interaction;
- ketoconazole;
- rifampin;
- olmesartan;
- OAT1;
- OATP1B1;
14.Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep

机译：应激性红细胞生成的药效学分析：绵羊两次静脉切开术后促红细胞生成素受体库大小的变化
- 作者：Mohammad I. Saleh;John A. Widness;Peter Veng-Pedersen
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第3期
- erythropoietin receptor;
- dosing optimization;
- pharmacodynamics;
- pharmacokinetics;
- sheep;
15.Pharmacokinetic properties of lutein emulsion after oral administration to rats and effect of food intake on plasma concentration of lutein

机译：叶黄素乳剂对大鼠口服后的药代动力学特性和食物摄入对叶黄素血浆浓度的影响
- 作者：Yuki Sato;Masaki Kobayashi;Shirou Itagaki;Takeshi Hirano;Toshihiro Noda;Satoshi Mizuno;Mitsuru Sugawara;Ken Iseki
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第3期
- lutein;
- carotenoid;
- bioavailability;
- absorption;
16.Sugammadex is cleared rapidly and primarily unchanged via renal excretion?

机译：Sugammadex可通过肾脏排泄迅速清除并基本保持不变？
- 作者：Pierre Peeters;Paul Passier;Jean Smeets;Alex Zwiers;Marcel de Zwart;Saskia van de Wetering-Krebbers;Marlou van Iersel;Sjoerd van Marle;Diels van den Dobbelsteen
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第3期
- sugammadex;
- Org 25969;
- pharmacokinetics;
- gamma-cyclodextrin;
17.Pharmacokinetic interactions between ciprofloxacin and itraconazole in healthy male volunteers

机译：环丙沙星和伊曲康唑在健康男性志愿者中的药代动力学相互作用
- 作者：Somchai Sriwiriyajan;Maseetoh Samaeng;Wibool Ridtitid;Werawath Mahatthanatrakul;Malinee Wongnawa
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第3期
- pharmacokinetics;
- ciprofloxacin;
- itraconazole;
- drug interaction;
18.Diverse approaches for the enhancement of oral drug bioavailability

机译：增强口服药物生物利用度的多种方法
- 作者：Pius Fasinu Viness Pillay;Valence M. K. Ndesendo Lisa C. du Toit Yahya E. Choonara
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第4期
- absorption;
- bioavailability;
- cytochrome P450;
- efflux transporters;
- enzymes;
- inhibitors;
- permeation enhancers;
- P-glycoproteins;
- poorly water-soluble drugs;
- pre-systemic metabolism;
19.Pancreatoduodenectomy as a source of human small intestine for Ussing chamber investigations and comparative studies with rat tissue

机译：胰十二指肠切除术作为人类小肠的来源，用于鼠室研究和与大鼠组织的比较研究
- 作者：Iain S. Haslam;Derek A. OReilly;David J. Sherlock;Ambareen Kauser;Chris Womack;Tanya Coleman
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第4期
- Ussing chamber;
- absorption;
- drug development;
- pancreatoduodenectomy;
20.Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding

机译：与成人相比，新生儿中的米卡芬净清除率更高：年龄依赖性米卡芬净血清结合的作用
- 作者：Souzan B. Yanni;P. Brian Smith;Daniel K. Benjamin Jr;Patrick F. Augustijns;Dhiren R. Thakker;Pieter P. Annaert
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第4期
- micafungin;
- pediatric drug disposition;
- serum binding;
- clearance prediction;
- antifungal;
21.Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine

机译：文拉法辛诱导药物外排蛋白表达，但去甲文拉法辛不诱导
- 作者：Corbin J. Bachmeier;David Beaulieu-Abdelahad;Nowell J. Ganey;Michael J. Mullan;Gary M. Levin
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第4期
- venlafaxine;
- desvenlafaxine;
- P-glycoprotein (P-gp);
- breast cancer resistance protein (BCRP);
- blood–brain barrier (BBB);
22.Effects of oral curcumin on the pharmacokinetics of intravenous and oral etoposide in rats: possible role of intestinal CYP3A and P-gp inhibition by curcumin

机译：口服姜黄素对大鼠静脉内和口服依托泊苷药代动力学的影响：姜黄素对肠道CYP3A和P-gp抑制的可能作用
- 作者：Chong-Ki Lee;Sung-Hwan Ki;Jun-Shik Choi
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第4期
- etoposide;
- curcumin;
- bioavailability;
- pharmacokinetics;
- CYP3A;
- P-gp;
- rats;
23.Differential pharmacokinetic analysis of in vivo erythropoietin receptor interaction with erythropoietin and continuous erythropoietin receptor activator in sheep

机译：绵羊体内促红细胞生成素受体与促红细胞生成素和连续促红细胞生成素受体激活剂相互作用的差异药代动力学分析
- 作者：Mohammed H. El-Komy;Robert L. Schmidt;John A. Widness;Peter Veng-Pedersen
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第5期
- erythropoietin;
- erythropoiesis stimulating agent (ESA);
- CERA;
- pharmacokinetics;
- receptor;
- physiological model;
- receptor binding;
- recirculation model;
24.Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates

机译：膳食植物化学吲哚I3C和DIM的药效学：诱导Nrf2介导的II期药物代谢和抗氧化基因以及与异硫氰酸酯的协同作用
- 作者：Constance Lay-Lay Saw;Melvilí Cintrón;Tien-Yuan Wu;Yue Guo;Ying Huang;Woo-Sik Jeong;Ah-Ng Tony Kong
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第5期
25.Fraction absorbed (F_abs): Different connotations and confusion for the literature?

机译：吸收的分数（F _{abs ）：文献有不同的内涵和困惑吗？}
- 作者：K. Sandy Pang;Amin Rostami-Hodjegan
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第5期
26.Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells

机译：二甲双胍在人肠上皮Caco-2细胞中的膜转运机制
- 作者：Asuka Horie Jumpei Sakata Maki Nishimura Kazuya Ishida Masato Taguchi Yukiya Hashimoto
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第5期
- metformin;
- organic cation transporter;
- Caco-2 cell;
27.Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible

机译：达诺普韦的局部药物生物利用度的生理模型和评估，以确定控释制剂是否可行
- 作者：Micaela B. Reddy;Alyson Connor;Barbara J. Brennan;Peter N. Morcos;Amy Zhou;Pamela McLawhon;Adrian Fretland;Philip Evans;Patrick Smith;Jonathan Q. Tran
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第5期
- danoprevir;
- hepatitis C;
- Enterion?;
- controlled release;
- absorption modeling;
28.Pharmacokinetic study of a novel sonosensitizer chlorin-e6 and its sonodynamic anti-cancer activity in hepatoma-22 tumor-bearing mice

机译：新型声敏剂二氢卟酚-e6的药代动力学研究及其在荷肝癌22小鼠中的声动力学抗癌活性
- 作者：Haitao Shi Quanhong Liu;Xiaofei Qin Pan Wang Xiaobing Wang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第6期
- sonodynamic therapy;
- chlorin-e6;
- anti-tumor effect;
- pharmacokinetic studies;
- in vivo optical imaging;
- hepatoma-22 solid tumor;
29.Predicting human plasma protein binding of drugs using plasma protein interaction QSAR analysis (PPI-QSAR)

机译：使用血浆蛋白相互作用QSAR分析（PPI-QSAR）预测药物与人血浆蛋白的结合
- 作者：Haiyan Li;Zhuxi Chen;Xuejun Xu;Xiaofan Sui;Tao Guo;Wei Liu;Jiwen Zhang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第6期
30.Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

机译：重组表达的人肝微粒体细胞色素P450 2C9的单位酶催化活性是否存在差异？系统间外推因素的系统研究
- 作者：H. K. Crewe;Z. E. Barter;K. Rowland Yeo;A. Rostami-Hodjegan
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第6期
31.Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site

机译：N-芳香族酰基-氨基酸缀合物对大鼠盲肠内容物的解偶联作用的结构效应：对结肠特异性前药设计的影响，目标位置的转化率可控
- 作者：Hyesik Kong Hyunjeong Kim Heejeong Do Yonghyun Lee Sungchae Hong Jeong-Hyun Yoon Yunjin Jung;Young Mi Kim
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第6期
- N-aromatic acyl-amino acid conjugates;
- colonic delivery;
- structural effect;
- colon specific prodrug;
- drug design;
32.MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines

机译：异种生物药物在不同的人类细胞系中微小RNA表达的差异
- 作者：Alice C. Rodrigues;Xin Li;Laura Radecki;Yu-Zhuo Pan;Jerrold C. Winter;Min Huang;Ai-Ming Yu
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第6期
- miRNA;
- drug disposition;
- metabolism;
- regulation;
- xenobiotic;
33.Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro

机译：（6R）-6- [N-（2-氯-4-氟苯基）氨磺酰基]环己-1-烯-1-羧酸乙酯（TAK-242）的化学反应
- 作者：Fumihiro Jinno;Tomoki Yoneyama Akio Morohashi Takahiro Kondo Satoru Asahi
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第7期
- covalent binding;
- glutathione;
- serum albumin;
- allylic rearrangement;
- reactivity;
34.Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles

机译：皮肤渗透阻滞剂和增强剂的开发和表征：负载左甲状腺素的PNIPAM，PLA，PLGA和EC微粒的比较研究
- 作者：Anahita Fathi Azarbayjani;Jia Vu Khu;Yew Weng Chan;Sui Yung Chan
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第7期
- penetration enhancers;
- penetration retardants;
- ethyl cellulose;
- poly d, l lactide;
- poly (N-isopropylacrylamide);
35.In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine

机译：洛沙平氧化代谢中涉及的人细胞色素p450酶的体外鉴定
- 作者：Jiang Ping Luo;Sarvesh C. Vashishtha;Edward M. Hawes;Gordon McKay;Kamal K. Midha;Jim Fang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第7期
- loxapine;
- cytochrome P450;
- metabolism;
- in vitro;
- human;
36.Tissue disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and topical administration in rats

机译：大鼠静脉和局部给药后驱虫剂DEET和防晒剂oxybenzone的组织处置
- 作者：Daryl J. Fediuk;Tao Wang;Yufei Chen;Fiona E. Parkinson;Michael P. Namaka;Keith J. Simons;Frank J. Burczynski;Xiaochen Gu
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第7期
- insect repellent DEET;
- sunscreen oxybenzone;
- tissue disposition;
- intravenous and topical administration;
- cellular toxicity;
37.Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infections, in lung epithelial lining fluid and alveolar macrophages

机译：克拉霉素和阿奇霉素，用于治疗呼吸道感染的大环内酯类抗菌剂在肺上皮衬里液和肺泡巨噬细胞中的分布特征
- 作者：Kohei Togami Sumio Chono;Kazuhiro Morimoto
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第7期
- clarithromycin;
- azithromycin;
- macrolide antimicrobial agents;
- lung epithelial lining fluid;
- alveolar macrophages;
38.The sulfated conjugate of biochanin A is a substrate of breast cancer resistant protein (ABCG2)

机译：Biochanin A的硫酸化缀合物是抗乳腺癌蛋白（ABCG2）的底物
- 作者：Guohua An Marilyn E. Morris
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第8期
- breast cancer resistance protein;
- flavonoid;
- transport;
- sulfation;
- biochanin A;
39.Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines

机译：抗逆转录病毒药物和药用植物之间的潜在药代动力学相互作用，用作补充和非洲传统药物
- 作者：Adrienne C. Müller Isadore Kanfer
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第8期
- antiretrovirals;
- CYP3A4;
- drug interactions;
- medicinal plants;
- P-gp;
40.Fenofibrate-induced decrease of expression of CYP2C11 and CYP2C6 in rat

机译：非诺贝特诱导大鼠CYP2C11和CYP2C6表达下降
- 作者：Rostislav Ve?e?a Alice Zacha?ová;Jan Orolin Jan Strojil Nina ?kottová Pavel Anzenbacher
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第8期
- fenofibrate;
- cytochrome P450;
- CYP2C11;
- CYP2C6;
- rat;
41.Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones

机译：黄S及其生物活性黄酮的药理作用和药代动力学性质
- 作者：Chenrui Li;Ge Lin;Zhong Zuo
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第8期
- Radix Scutellariae;
- pharmacokinetics;
- pharmacological effect;
- drug–herb interaction;
42.Integrated model for denosumab and ibandronate pharmacodynamics in postmenopausal women

机译：绝经后妇女地诺单抗和伊班膦酸药效动力学综合模型
- 作者：Dhananjay D. Marathe;Anshu Marathe;Donald E. Mager
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第8期
- bisphosphonates;
- bone remodeling;
- bone mineral density;
- denosumab;
- pharmacodynamics;
43.Bottom-up modeling and simulation of tacrolimus clearance: prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power

机译：他克莫司清除率的自下而上的建模和模拟：前瞻性研究血细胞分布，性别和CYP3A5表达作为协变量并评估研究能力
- 作者：Hisakazu Ohtani;Zoe Barter;Tsuyoshi Minematsu;Masatoshi Makuuchi;Yasufumi Sawada;Amin Rostami-Hodjegan
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第9期
44.Pharmacokinetic profile of SKP-1041, a modified release formulation of zaleplon

机译：扎来普仑调释制剂SKP-1041的药代动力学
- 作者：David J. Greenblatt;Jerold S. Harmatz;James K. Walsh;Rémy Luthringer;Luc Staner;Sarah Otmani;Jean-Fran?ois Nedelec;Céline Francart;Sarah J. Parent;Corinne Staner
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第9期
- zaleplon;
- insomnia;
- middle-of-the-night awakening;
- pharmacokinetics;
45.The extended ocular hypotensive effect of positive liposomal cholesterol bound timolol maleate in glaucomatous rabbits

机译：脂质体胆固醇结合的马来酸替莫洛尔对青光眼兔的扩展眼压降低作用
- 作者：Medhat W. Shafaa;Neveen M. Sabra;Rehab A. Fouad
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第9期
- liposomes;
- timolol maleate;
- glaucomatous rabbits;
- intraocular pressure;
- DSC;
46.Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3

机译：氟比洛芬，布洛芬和萘普生对人有机阴离子转运蛋白hOAT1和hOAT3的立体选择性抑制作用
- 作者：Hiroaki Honjo Yuichi Uwai;Youhei Aoki Kikuo Iwamoto
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第9期
- organic anion transporter;
- transport;
- NSAID;
- inhibition;
- stereoselectivity;
47.Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects

机译：anacetrapib对健康受试者地高辛药代动力学的影响缺乏
- 作者：Rajesh Krishna;Daria Stypinski;Melissa Ali;Amit Garg;Isaias Noel Gendrano III;Andrea Maes;Bruce DeGroot;Yang Liu;Susie Li;Sandra M. Connolly;John A. Wagner;S. Aubrey Stoch
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第9期
- anacetrapib;
- digoxin;
- co-administration;
48.Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells

机译：在过表达杆状病毒感染的Sf9细胞膜囊泡中检测到的橙皮素葡萄糖醛酸苷缀合物与人BCRP，MRP2和MRP3的相互作用
- 作者：Walter Brand;Berend Oosterhuis;Peter Krajcsi;Denis Barron;Fabiola Dionisi;Peter J. van Bladeren;Ivonne M. C. M. Rietjens;Gary Williamson
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2011年第9期
- flavonoid;
- glucuronide conjugate;
- ABC transporters;
- MRP3;
- ATPase activity;
49.Effects of 1α,25-dihydroxyvitamin D₃ on transporters and enzymes of the rat intestine and kidney in vivo

机译：1α，25-二羟基维生素D _{3 对体内大鼠小肠和肾脏转运蛋白和酶的影响}
- 作者：Edwin C. Y. Chow;Huadong Sun;Ansar A. Khan;Geny M. M. Groothuis;K. Sandy Pang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第1期
- 1α,25-dihydroxyvitamin Dsub3/sub;
- vitamin D receptor;
- intestine;
- colon;
- kidney;
- transporters;
- enzymes;
- nuclear receptors;
- Asbt;
- Mrp;
- PepT1;
- Oat;
- Mdr1a;
- P-gp;
- cytochrome P450 enzymes;
- Cyp24 and Cyp3a9;
50.Pharmacokinetics, bioavailability and effects on electrocardiographic parameters of oral fludarabine phosphate

机译：口服氟达拉滨磷酸酯的药代动力学，生物利用度及其对心电图参数的影响
- 作者：Wei Yin;Elena V. Karyagina;Ante S. Lundberg;David J. Greenblatt;John Lister-James
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第1期
- electrocardiography;
- QT interval;
- fludarabine phosphate;
- pharmacokinetics;
- bioavailability;
51.Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology

机译：有机阴离子转运蛋白：发现，药理学，调控及其在病理生理学中的作用
- 作者：Adam L. VanWert;Michael R. Gionfriddo;Douglas H. Sweet
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第1期
- renal transport;
- secretion;
- solute carrier;
- Slc22;
- liver;
52.Structure–pharmacokinetic relationship of in vivo rat biliary excretion

机译：体内大鼠胆汁排泄的结构-药代动力学关系
- 作者：Yue Chen Kimberly Cameron Angel Guzman-Perez David Perry Dong Li Hua Gao
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第1期
53.Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin

机译：临床前证据可证明P-糖蛋白底物他尼洛尔与莫林合用可提高口服生物利用度
- 作者：Shriram M. Pathak;Shriram M. Pathak
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- Morin;
- Talinolol;
- P-glycoprotein;
- Bioavailability;
54.Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes

机译：夹心培养的大鼠和人类肝细胞中八种HIV蛋白酶抑制剂与小管外流转运蛋白ABCC2（MRP2）的相互作用
- 作者：Zhi-wei Ye;Sandrine Camus;Patrick Augustijns;Pieter Annaert
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- ABCC2;
- biliary excretion;
- drug interaction;
- drug transport;
- HIV protease inhibitors;
- MRP2;
55.Simple pharmacometric tools for oral anti-diabetic drug development: competitive landscape for oral non-insulin therapies in type 2 diabetes

机译：口服抗糖尿病药物开发的简单药理学工具：2型糖尿病口服非胰岛素疗法的竞争格局
- 作者：Mahesh N. Samtani
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- PK/PD;
- meta-analysis;
- pharmacometrics;
- clinical trial;
- type 2 diabetes;
56.Simulation of sirolimus exposures and population variability immediately post renal transplantation: importance of the patient's CYP3A5 genotype in tailoring treatment

机译：肾移植后立即模拟西罗莫司暴露和人群变异：患者CYP3A5基因型在定制治疗中的重要性
- 作者：John C. Lukas;Rosario Calvo;Anastasios Zografidis;Ignacio Ortega;Elena Suárez
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- sirolimus;
- renal transplantation;
- CYP3A5 genotype;
- simulation;
- dose titration;
57.Pharmacokinetic study on the mechanism of interaction of sulfacetamide sodium with bovine serum albumin: a spectroscopic method

机译：磺乙酰胺钠与牛血清白蛋白相互作用机理的药代动力学研究：光谱法
- 作者：Praveen N. Naik Shivamurti A. Chimatadar Sharanappa T. Nandibewoor
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
58.Pharmacokinetics and pharmacodynamics of controlled release insulin loaded PLGA microcapsules using dry powder inhaler in diabetic rats

机译：干粉吸入器在糖尿病大鼠中控释胰岛素负载的PLGA微胶囊的药代动力学和药效学
- 作者：Hamed Hamishehkar;Jaber Emami;Abdolhossien Rouholamini Najafabadi;Kambiz Gilani;Mohsen Minaiyan;Kambiz Hassanzadeh;Hamid Mahdavi;Maryam Koohsoltani;Ali Nokhodchi
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- insulin;
- PLGA;
- controlled release;
- pulmonary delivery;
- dry powder inhalation;
59.Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters

机译：血管紧张素1型受体阻滞剂与ATP结合盒转运蛋白的相互作用
- 作者：J. Weiss;A. Sauer;N. Divac;M. Herzog;E. Schwedhelm;R. H. Böger;W. E. Haefeli;R. A. Benndorf
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- angiotensin receptor blockers;
- telmisartan;
- ABC-transporters;
- P-glycoprotein;
- drug interactions;
60.Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole

机译：含有来曲唑的透皮贴剂的配方和生物制药评价
- 作者：Li Li;Liang Fang;Xinlan Xu;Yu Liu;Yinghua Sun;Zhonggui He
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- letrozole;
- transdermal patch;
- pharmacokinetic;
- in vitro;
- in vivo;
61.Prolonged absorption of antimony(V) by the oral route from non-inclusion meglumine antimoniate–β-cyclodextrin conjugates

机译：非包合葡甲胺锑酸盐-β-环糊精偶联物通过口服途径延长了对锑（V）的吸收
- 作者：Raul R. Ribeiro;Weverson A. Ferreira;Patricia S. Martins;Rubens L. M. Neto;Olguita G. F. Rocha;Laurence Le Moyec;Cynthia Demicheli;Frédéric Frézard
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第3期
- cyclodextrin;
- meglumine antimoniate;
- oral route;
- pharmacokinetics;
- dogs;
62.Involvement of an influx transporter in the blood–brain barrier transport of naloxone

机译：涌入转运蛋白参与纳洛酮的血脑屏障转运
- 作者：Toyofumi Suzuki;Aya Ohmuro;Mariko Miyata;Takayuki Furuishi;Shinji Hidaka;Fumihiko Kugawa;Toshiro Fukami;Kazuo Tomono
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第4期
- blood–brain barrier;
- influx transport;
- brain uptake index;
- naloxone;
- opioid antagonist;
63.Interplay of transporters and enzymes in the Caco-2 cell monolayer: I. effect of altered apical secretion

机译：Caco-2细胞单层中转运蛋白和酶的相互作用：I.根尖分泌改变的影响
- 作者：Jianghong Fan Han-Joo Maeng K. Sandy Pang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第4期
- transporter–enzyme interplay;
- metabolism;
- excretion;
- Caco-2;
- catenary model;
- linear and non-linear conditions;
- see-saw phenomenon;
64.Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited

机译：预测人类对治疗性蛋白质的清除率：重新探讨了简单的异度缩放法
- 作者：Weirong Wang;Weirong Wang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第4期
- human clearance prediction;
- interspecies scaling;
- therapeutic proteins;
- allometry;
- pharmacokinetics;
65.Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats

机译：五味子醇B口服后大鼠紫杉醇的口服生物利用度提高
- 作者：Jing Jin Huichang Bi Jinqing Hu Guoping Zhong Lizi Zhao Zhiying Huang Min Huang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第4期
- paclitaxel;
- Schisandrol B;
- pharmacokinetics;
- bioavailability;
- rats;
66.Contributions of human cytochrome P450 enzymes to glyburide metabolism

机译：人类细胞色素P450酶对格列本脲代谢的贡献
- 作者：Lin Zhou;Suresh B. Naraharisetti;Li Liu;Honggang Wang;Yvonne S. Lin;Nina Isoherranen;Jashvant D. Unadkat;Mary F. Hebert;Qingcheng Mao
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第4期
- glyburide;
- human CYP enzymes;
- CYP3A4;
- CYP2C9;
- in vitro metabolism;
67.Effect of absorption site on the pharmacokinetics of sublingual asenapine in healthy male subjects

机译：吸收部位对健康男性受试者舌下阿塞那平药代动力学的影响
- 作者：Mireille Gerrits;Mireille Gerrits
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- asenapine;
- buccal;
- pharmacokinetics;
- sublingual;
- supralingual;
68.Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo

机译：异黄酮生物chaninA对米托蒽醌体内外转运的影响
- 作者：Guohua An Marilyn E. Morris
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- biochanin A;
- mitoxantrone transport;
- breast cancer resistance protein;
- pharmacokinetics;
69.Binding of licarbazepine enantiomers to mouse and human plasma proteins

机译：利卡西平对映体与小鼠和人类血浆蛋白的结合
- 作者：Ana Fortuna;Gilberto Alves;Amílcar Falcão;Patrício Soares-da-Silva
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- licarbazepine enantiomers;
- plasma protein binding;
- albumin;
- sub1/sub-acid glycoprotein;
70.Thromboelastographic and pharmacokinetic profiles of micro- and macro-emulsions of propofol in swine

机译：猪中异丙酚微乳和大乳的血栓弹力图和药代动力学
- 作者：Timothy E. Morey;Jerome H. Modell;Jorge E. Garcia;Michael Bewernitz;Hartmut Derendorf;Manoj Varshney;Nikolaus Gravenstein;Dinesh O. Shah;Donn M. Dennis
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- microemulsion;
- macroemulsion;
- propofol;
- swine;
- pharmacokinetics;
- thromboelastographic;
71.Time-dependent clearance and hematological pharmacodynamics upon erythropoietin multiple dosing in rats

机译：大鼠促红细胞生成素多次给药的时间依赖性清除率和血液学药效学
- 作者：Sihem Ait-Oudhia;Jean-Michel Scherrmann;Wojciech Krzyzanski
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- recombinant human erythropoietin;
- pharmacokinetics;
- erythropoiesis;
- tolerance effect;
- rebound phenomena;
72.Interrelations between plasma caffeine concentrations and neurobehavioural effects in healthy volunteers: model analysis using NONMEM

机译：健康志愿者血浆咖啡因浓度与神经行为的相关性：使用NONMEM的模型分析
- 作者：Kok-Yong Seng;Wei-Ling Grace Teo;Chiok-Yuen David Fun;Yu-Li Lydia Law;Chin-Leong Lim
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- caffeine;
- neurobehavioural tests;
- mixed-effects model;
- pharmacokinetics and pharmacodynamics;
- NONMEM;
73.Validation of a differential in situ perfusion method with mesenteric blood sampling in rats for intestinal drug interaction profiling

机译：肠系膜间血样差分原位灌注方法对大鼠肠道药物相互作用谱的验证
- 作者：Joachim Brouwers Raf Mols Pieter Annaert Patrick Augustijns
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- biopharmaceutics;
- intestinal absorption;
- drug interactions;
- permeability;
- in situ perfusion;
74.Dose-dependent pharmacokinetics of SP-8203 in rats

机译：SP-8203在大鼠中的剂量依赖性药代动力学
- 作者：Joo H. Lee;Young H. Choi;Jung H. Suh;Hee E. Kang;Tae H. Lee;Il H. Cho;Myung G. Lee
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- SP-8203;
- dose-dependent pharmacokinetics;
- intravenous and oral administration;
- rats;
75.Prediction of human blood-to-plasma drug concentration ratio

机译：人体血浆与血浆药物浓度比的预测
- 作者：Takahide Uchimura;Motohiro Kato;Tomohisa Saito;Haruki Kinoshita
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- liver model;
- blood-to-plasma concentration ratio;
- log D;
- protein binding;
- bootstrap;
76.Sotrastaurin and cyclosporine drug interaction study in healthy subjects

机译：Sotrastaurin与环孢素药物相互作用在健康受试者中的研究
- 作者：John M. Kovarik;Sylvie Stitah;Alan Slade;Alessandra Vitaliti;Frank Straube;Olivier Grenet;Serge Winter;Nikolaos Sfikas;Michael Seiberling
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第6期
- sotrastaurin;
- cyclosporine;
- drug interactions;
- protein kinase C;
77.A new C-peptide correction model used to assess bioavailability of regular human insulin

机译：一种新的C肽校正模型，用于评估普通人胰岛素的生物利用度
- 作者：M. T. Marino;M. T. Marino
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第7期
- C-peptide;
- insulin;
- bioavailability;
78.The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic–pharmacodynamic modeling

机译：基于药代动力学-药效学模型的临床前数据预测人类对ONO-4641（鞘氨醇1-磷酸受体调节剂）的反应
- 作者：Tomoya Ohno;Tomoya Ohno
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第7期
- pharmacokinetic;
- pharmacodynamic;
- translational drug research;
- multiple sclerosis;
- sphingosine 1-phosphate;
79.Effects of lovastatin on the pharmacokinetics of nicardipine in rats

机译：洛伐他汀对尼卡地平大鼠药代动力学的影响
- 作者：Joong-W. Chung;Si H. Yang;Jun-S. Choi
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第7期
- pharmacokinetic interaction;
- nicardipine and lovastatin;
- CYP3A subfamily;
- P-gp;
- rats;
80.Formulation and evaluation of chitosan microspheres of aceclofenac for colon-targeted drug delivery

机译：醋氯芬酸壳聚糖微球在结肠靶向给药中的制备与评价
- 作者：S. K. Umadevi;R. Thiruganesh;S. Suresh;K. Bhaskar Reddy
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第7期
- aceclofenac;
- chitosan;
- microspheres;
- Eudragit coating;
- targeted delivery;
- colon targeting;
- in vitro dissolution;
81.Acyl glucuronides: the good, the bad and the ugly

机译：酰基葡萄糖醛酸：好，坏和丑陋
- 作者：Sophie L. Regan;James L. Maggs;Thomas G. Hammond;Craig Lambert;Dominic P. Williams;B. Kevin Park
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第7期
- carboxylic acid drugs;
- acyl glucuronide;
- adverse drug reactions;
- physiology;
- toxicology;
- glucuronyl transferase;
- protein adducts;
- pharmacokinetics;
- drug safety;
82.Effect of fluvastatin, lovastatin, nifedipine and verapamil on the systemic exposure of nateglinide in rabbits

机译：氟伐他汀，洛伐他汀，硝苯地平和维拉帕米对兔那格列奈全身暴露的影响
- 作者：Youngmin Kim;Kyemyung Park;Wonku Kang
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- nateglinide;
- fluvastatin;
- lovastatin;
- nifedipine;
- verapamil;
- rabbits;
83.Tumor necrosis factor alpha increases P-glycoprotein expression in a BME-UV in vitro model of mammary epithelial cells

机译：在乳腺上皮细胞体外模型中，肿瘤坏死因子α增加P-糖蛋白表达
- 作者：Mohammad M. Al-Bataineh;Deon van der Merwe;Bruce D. Schultz;Ronette Gehring
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- mammary epithelium;
- P-glycoprotein;
- pharmaco-/toxicokinetic;
- TNF-;
84.Contribution of molecular properties to extrapolation of the volume of distribution in human from preclinical animal species data

机译：从临床前动物物种数据推断分子特性对人体分布量的推断
- 作者：Xiaofan Sui;Jin Sun;Haiyan Li;Yang Pan;Yongjun Wang;Zhonggui He
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- volume of distribution;
- molecular descriptors;
- partial least squares;
- allometric method;
85.HIV protease inhibitors: garlic supplements and first-pass intestinal metabolism impact on the therapeutic efficacy

机译：HIV蛋白酶抑制剂：大蒜补充剂和首过肠代谢对治疗功效的影响
- 作者：Katja Berginc;Katja Berginc
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- saquinavir;
- darunavir;
- aged garlic extract;
- intestine;
- CYP3A4;
- intestine;
86.Absorption of CH330331, a novel 4-anilinoquinazoline inhibitor of epidermal growth factor receptor tyrosine kinase: comparative studies using in vitro, in situ and in vivo models

机译：新型表皮生长因子受体酪氨酸激酶的4-苯胺基喹唑啉抑制剂CH330331的吸收：使用体外，原位和体内模型的比较研究
- 作者：Haiyan Sun;Huichang Bi;Min Huang;Dong Liu;Zhenyu Qin
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- CH330331;
- Caco-2;
- single-pass rat intestinal perfusion model;
- bioavailability;
87.Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)_{7 m}-β-cyclodextrin or a co-solvent system

机译：（SBE）_{7 m -β-环糊精或共溶剂系统制剂中静脉注射美法仑的药代动力学的临床前比较}
- 作者：Maria Koltun;Julia Morizzi;Kasiram Katneni;Susan A. Charman;David M. Shackleford;Michelle P. McIntosh
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- melphalan;
- cyclodextrins;
- pharmacokinetics;
- intravenous;
- rodent;
88.The use of saliva as a biological fluid in relative bioavailability studies: comparison and correlation with plasma results

机译：在相对生物利用度研究中将唾液用作生物流体：与血浆结果的比较和相关性
- 作者：M. Esperanza Ruiz;Paula Conforti;Pietro Fagiolino;M. Guillermina Volonté
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- saliva;
- in vitro–in vivo correlations;
- relative bioavailability;
- dissolution profiles;
- carbamazepine;
89.Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations

机译：确定用于预测虚拟人群代谢清除率的肝CYP3A5 * 1 / * 3和CYP3A4表达之间的定量关系
- 作者：Z. E. Barter;H. F. Perrett;K. Rowland Yeo;D. Allorge;M. S. Lennard;A. Rostami-Hodjegan
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- CYP metabolism;
- in vitro–in vivo extrapolation;
- inter-individual variability;
- correlation;
- tacrolimus;
90.Altered electrolyte handling of the choroid plexus in rats with glycerol-induced acute renal failure

机译：甘油引起的急性肾功能衰竭大鼠脉络丛电解质改变
- 作者：Atsuko Ishikawa Kentaro Kono Rie Sakae Tetsuya Aiba;Atsuko Ishikawa Kentaro Kono Rie Sakae Tetsuya Aiba
- 期刊名称：《Biopharmaceutics & Drug Disposition》 | 2010年第9期
- NKCC1;
- cerebrospinal fluid;
- acute renal failure;
- lithium;
- rubidium;

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