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首页> 外文期刊>International Journal of Molecular Sciences >Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern
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Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern

机译：类风湿关节炎亚型中医感冒涉及的氨基酸，碳水化合物和脂质代谢差异

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摘要

Pattern classification is a key approach in Traditional Chinese Medicine (TCM), and it is used to classify the patients for intervention selection accordingly. TCM cold and heat patterns, two main patterns of rheumatoid arthritis (RA) had been explored with systems biology approaches. Different regulations of apoptosis were found to be involved in cold and heat classification in our previous works. For this study, the metabolic profiling of plasma was explored in RA patients with typical TCM cold or heat patterns by integrating liquid chromatography/mass spectrometry (LC/MS) and gas chromatography/mass spectrometry (GC/MS) platforms in conjunction with the Ingenuity Pathway Analysis (IPA) software. Three main processes of metabolism, including amino acid, carbohydrate and lipid were focused on for function analysis. The results showed that 29 and 19 differential metabolites were found in cold and heat patterns respectively, compared with healthy controls. The perturbation of amino acid metabolism (increased essential amino acids), carbohydrate metabolism (galactose metabolism) and lipid metabolism, were found to be involved in both cold and heat pattern RA. In particular, more metabolic perturbations in protein and collagen breakdown, decreased glycolytic activity and aerobic oxidation, and increased energy utilization associated with RA cold pattern patients. These findings may be useful for obtaining a better understanding of RA pathogenesis and for achieving a better efficacy in RA clinical practice.
机译：模式分类是中医（TCM）的一种关键方法，用于对患者进行分类以进行干预选择。中医冷热模式是类风湿关节炎（RA）的两种主要模式，已通过系统生物学方法进行了探索。在我们以前的工作中，发现细胞凋亡的不同调控与冷热分类有关。对于本研究，结合独创性，结合液相色谱/质谱（LC / MS）和气相色谱/质谱（GC / MS）平台，对具有典型TCM冷或热模式的RA患者血浆代谢谱进行了研究。路径分析（IPA）软件。代谢的三个主要过程包括氨基酸，碳水化合物和脂质被集中用于功能分析。结果表明，与健康对照组相比，分别在冷和热模式下发现了29种和19种差异代谢物。氨基酸代谢的紊乱（必需氨基酸的增加），碳水化合物的代谢（半乳糖的代谢）和脂质的代谢被发现与冷热型RA都有关系。特别是，与RA感冒型患者相关的蛋白质和胶原蛋白分解代谢紊乱，糖酵解活性和有氧氧化作用降低以及能量利用增加。这些发现可能有助于更好地了解RA发病机理，并在RA临床实践中获得更好的疗效。

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