• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacoepidemiology and drug safety >Wheezing lower respiratory disease and vaccination of full-term infants.
【24h】

Wheezing lower respiratory disease and vaccination of full-term infants.

机译：喘息性下呼吸道疾病和足月儿疫苗接种。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: There have been speculations that increases in vaccinations have caused recent increases in wheezing lower respiratory disease during infancy. We assess possible associations between vaccines and incidence of wheezing in full-term infants. METHODS: We conducted a matched case-control study of full-term infants born into the Kaiser Permanente Northwest health plan during 1991-1994 and continuously enrolled for at least 12 months (n = 1366 case-control pairs). Potential cases of wheeze were ascertained from medical care databases and verified by chart review. Vaccinations, demographic factors, and wheeze risk factors were abstracted from charts. Adjusted relative risks of first onset of wheeze during post-vaccination exposure windows were estimated by conditional logistic regression. We also conducted case-series analyses of wheeze onsets. RESULTS: We found no evidence that risk of wheeze during infancy is associated with recency of vaccination with whole-cell pertussis (DTP), hepatitis b (HBV),Haemophilus influenzae type b (HIB), oral polio (OPV), or measles, mumps and rubella (MMR) vaccines. We also found no evidence that risk of first wheeze is associated with exposure to HBV or MMR. CONCLUSIONS: Recent increases in wheezing during infancy do not appear to be related to increases in vaccinations of full-term infants.
机译：目的：有人猜测，接种疫苗的增加导致婴儿期喘息性下呼吸道疾病的近期增加。我们评估了疫苗与足月儿喘息发生率之间的可能联系。方法：我们进行了一项配对病例对照研究，研究了1991-1994年进入Kaiser Permanente Northwest保健计划并连续入组至少12个月（n = 1366个病例对照对）的足月婴儿。从医疗数据库确定潜在的喘息病例，并通过图表审查进行验证。从图表中提取疫苗，人口统计学因素和喘息危险因素。疫苗接种后接触窗期间首次发作喘息的相对风险通过条件逻辑回归进行估算。我们还进行了喘息发作的病例系列分析。结果：我们没有发现证据表明婴儿期发生喘息的风险与全细胞百日咳（DTP），乙型肝炎（HBV），乙型流感嗜血杆菌（HIB），口服脊髓灰质炎（OPV）或麻疹的近期疫苗接种有关，腮腺炎和风疹（MMR）疫苗。我们也没有发现证据表明初发喘息的风险与接触HBV或MMR有关。结论：婴儿期气喘的近期增加似乎与足月婴儿疫苗接种的增加无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号