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首页> 外文期刊>Pharmacoepidemiology and drug safety >Multicentre evaluation of prescribing concurrence with anti-infective guidelines: epidemiological assessment of indicators.
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Multicentre evaluation of prescribing concurrence with anti-infective guidelines: epidemiological assessment of indicators.

机译：处方中心同意抗感染指南的多中心评估：指标的流行病学评估。

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PURPOSE: To assess indicators for anti-infective prescribing not concurrent with regional pharmacotherapeutic treatment guidelines (PTGs) on infectious diseases. METHODS: A retrospective explorative cohort study based on hospital-wide anti-infective prescription data of a 2-month cross-sectional period (n = 1037). Risk rates (absolute risks: AR), risk rate ratios (relative risks: RR) and odds ratios (OR) with 95% confidence intervals (95%CI) were estimated for patient, disease, drug, and prescriber variables considered to be potential indicators. Univariable and multivariable logistic regression analyses were performed. FINDINGS: Non-concurrence existed of non-indicated prescribing of (particular) anti-infectives (24.3%) and prescribing of non-first choice anti-infectives (55.2%). Non-concurrent durations of treatment and dosing issues accounted for 17.2% and 16.2% respectively. Non-concurrence was associated with empirical therapy, with certain diagnoses, such as skin and soft tissue, urinary, and osteoarthrological infections, and with prescriptions involving topical dosage forms, cephalosporins, macrolides and lincosamides, and quinolones. There was also an association with certain hospitals and with prescribing by geriatricians, surgeons, pulmonologists, and urologists and, in general, junior clinicians in training. CONCLUSIONS: Other hospitals could use our epidemiological framework to identify their own indicators for non-concurrent prescribing. Our findings suggest tailor-made enforcement of PTG adherence for certain prescribers while conversely, adaptation of the PTGs will be required for some infectious diseases.
机译：目的：评估与感染性疾病的区域性药物治疗指南（PTGs）不同的抗感染处方指标。方法：一项回顾性探索性队列研究，基于整个医院范围内为期2个月（n = 1037）的抗感染处方数据。估计患者，疾病，药物和处方药变量的潜在风险率（绝对风险：AR），风险率比（相对风险：RR）和比值比（OR）以及95％置信区间（95％CI）指标。进行了单变量和多变量逻辑回归分析。结果：未明确指出（特殊）抗感染药的处方（24.3％）和非首选抗感染药的处方（55.2％）。非并行治疗持续时间和给药剂量分别占17.2％和16.2％。不并发与经验疗法，某些诊断（例如皮肤和软组织，泌尿系统和骨关节炎感染）以及涉及局部剂型，头孢菌素，大环内酯和林可酰胺和喹诺酮类药物的处方有关。还与某些医院有联系，并由老年病医生，外科医生，肺病学家和泌尿科医师开具处方，并且一般来说，初级初级临床医生正在接受培训。结论：其他医院可以使用我们的流行病学框架来确定自己的非并行处方指标。我们的发现表明，对于某些处方者，PTG的依从性是量身定制的，相反，对于某些传染病，PTG的适应性将是必需的。

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