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首页> 外文期刊>Pharmacoepidemiology and drug safety >Birth defect classification by organ system: a novel approach to heighten teratogenic signalling in a pregnancy registry.
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Birth defect classification by organ system: a novel approach to heighten teratogenic signalling in a pregnancy registry.

机译：按器官系统分类的出生缺陷：在妊娠登记中提高致畸信号的新方法。

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摘要

The Antiretroviral Pregnancy Registry (APR) is an ongoing international prospective exposure-registration cohort study that monitors outcomes of pregnancies exposed to marketed antiretroviral medications. The population of women exposed to antiretrovirals remains relatively small, which limits the power of the registry. In order to maximize identification of a teratogenic signal, a special birth defect classification system was devised. Birth defects were organized based upon organ system and embryology, using the Metropolitan Atlanta Congenital Defects Program as a model. Grouping defects that share embryology and pathogenesis increases the likelihood that a teratogenic effect will be apparent. The result is a three-tiered system: organ system, preferred defect term, and reported defect term. This system is text based, which eliminates the need to memorize codes and allows use by anyone familiar with medical terminology. Once established, the new APR Organ System Classification retains enough flexibility that categories may be collapsed or expanded as experience grows. Standardized nomenclature also minimizes variation introduced by collecting defect reports from many different sources.
机译：抗逆转录病毒孕妇注册（APR）是一项正在进行的国际前瞻性暴露注册队列研究，旨在监测暴露于市售抗逆转录病毒药物的孕妇的妊娠结局。接触抗逆转录病毒药物的妇女人数仍然相对较少，这限制了登记处的权力。为了最大程度地识别致畸信号，设计了一种特殊的出生缺陷分类系统。以大都会亚特兰大先天性缺陷计划为模型，根据器官系统和胚胎学来组织出生缺陷。将具有胚胎学和发病机理的缺陷归为一组，增加了致畸作用明显的可能性。结果是一个三层系统：器官系统，首选缺陷项和报告的缺陷项。该系统基于文本，无需记忆代码，任何熟悉医学术语的人都可以使用。一旦建立，新的APR器官系统分类将保留足够的灵活性，以使类别可以随着经验的增长而崩溃或扩展。标准化的术语还可以通过收集来自许多不同来源的缺陷报告来最小化引入的差异。

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