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首页> 外文期刊>Pharmacoepidemiology and drug safety >Moderate alcohol consumption and adverse drug reactions among older adults.
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Moderate alcohol consumption and adverse drug reactions among older adults.

机译：老年人中度饮酒和药物不良反应。

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PURPOSE: To assess the effect of moderate alcohol consumption on Adverse Drug Reactions (ADRs) among older adults admitted to acute care hospitals and to examine the consistency of this effect across gender and age groups. METHODS: We used the GIFA (Italian Group of Pharmacoepidemiology in the Elderly) database, which includes information on patients admitted to 81 medical centers in Italy. For this study we examined exclusively the ADRs detected at hospital admission that were classified as definite or probable based on the Naranjo algorithm. RESULTS: Among 22,778 participants, 894 were found to have one or more ADRs (3.9%). Gastrointestinal complications (n = 210; 0.9% of the population) were the most frequent ADRs, followed by metabolic/endocrine (n = 156; 0.7%), dermatological/allergic (n = 102; 0.4%) and arrhythmic (n = 78; 0.3%) complications. Diuretics were the most frequent culprit drugs, followed by NSAIDs and digoxin. An ADR was recorded in 383/10,427 (3.7%) non-drinkers and in 511/12,351 (4.1%) moderate drinkers. After adjusting for potential confounders, moderate alcohol consumption was associated with a 24% increased risk of ADRs (OR 1.24; 95%CI: 1.08-1.43). This effect seemed more evident among women (OR 1.30; 95%CI: 1.09-1.55), than men (OR 1.14; 95%CI: 0.90-1.43), while it was similar across different age groups (< 65 years OR 1.28; 95%CI: 0.99-1.66; 65-79 years OR 1.22; 95%CI: 0.98-1.52; > or = 80 years OR 1.20; 95%CI: 0.93-1.56). Considering the most common ADRs, moderate alcohol users presented a significantly higher risk of drug-related headache (OR 3.89; 95%CI: 1.43-10.61) and metabolic/endocrine complications (OR 1.67; 95%CI: 1.19-2.33). CONCLUSIONS: Moderate alcohol intake is associated with an increased risk of ADRs; this effect seems more evident among women than men, and it does not differ across age groups.
机译：目的：评估适度饮酒对入住急诊医院的老年人的不良药物反应（ADR）的影响，并检查该影响在性别和年龄组中的一致性。方法：我们使用了GIFA（意大利药典流行病学小组）数据库，该数据库包含有关意大利81个医疗中心收治的患者的信息。在本研究中，我们仅检查了根据Naranjo算法在住院时发现的ADR，这些ADR被归类为确定的或可能的ADR。结果：在22,778名参与者中，有894名具有一种或多种ADR（3.9％）。胃肠道并发症（n = 210;占人口的0.9％）是最常见的ADR，其次是代谢/内分泌（n = 156; 0.7％），皮肤病/过敏（n = 102; 0.4％）和心律不齐（n = 78） ; 0.3％）并发症。利尿剂是最常见的罪魁祸首，其次是非甾体抗炎药和地高辛。在383 / 10,427（3.7％）的非饮酒者和511 / 12,351（4.1％）的中度饮酒者中记录了ADR。在调整了潜在的混杂因素之后，适度饮酒会增加24％的ADR风险（OR 1.24; 95％CI：1.08-1.43）。女性（OR 1.30; 95％CI：1.09-1.55）比男性（OR 1.14; 95％CI：0.90-1.43）似乎更明显，而不同年龄段（<65岁或1.28; 95％CI：0.99-1.66; 65-79岁或1.22; 95％CI：0.98-1.52;>或= 80年OR 1.20; 95％CI：0.93-1.56）。考虑到最常见的ADR，中度饮酒者出现与药物相关的头痛（OR 3.89; 95％CI：1.43-10.61）和代谢/内分泌并发症（OR 1.67; 95％CI：1.19-2.33）的风险明显更高。结论：适度饮酒与增加ADR的风险有关。在女性中，这种影响似乎比男性更明显，并且在各个年龄段中也没有差异。

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