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首页> 外文期刊>Pharmacoepidemiology and drug safety >Adverse drug reactions as a cause for admissions to a department of internal medicine.
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Adverse drug reactions as a cause for admissions to a department of internal medicine.

机译：药物不良反应是内科住院的原因。

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PURPOSE: To assess the occurrence and pattern of adverse drug reactions as a cause for acute hospital admission. METHODS: In 681 randomly selected patients, acutely admitted to a clinic of internal medicine at a Swedish university hospital, information was collected from their medical records about current symptoms and use of drugs, previous diseases and the results of medical investigations and tests. In addition, a standardized interview according to a questionnaire was carried out. A group of experts in clinical pharmacology assessed the data obtained from the patients' case records and the results of the interviews, and then, according to WHO criteria, judged the probability that an adverse drug reaction could have caused or contributed to the actual admission to hospital. RESULTS: Out of the 681 cases included, 94 (13.8%) had symptoms and signs that were judged as drug-related and that had caused or contributed to the admission. Eighty-two patients (12.0%) had altogether 99 symptoms that were classified as adverse drug reactions. Of these, 91% were type A reactions. The relationship between the medication and the reaction was judged certain in eight, probable in 17, and possible in 74 cases. The most common adverse drug reactions were cardiovascular (36.3%). Twelve patients (1.8%) had symptoms indicating intoxications. CONCLUSIONS: The prevalence of drug-related problems causing or contributing to admission to a clinic of internal medicine is high and is dominated by type A reactions, i.e. reactions in principle predictable and preventable. This implies a possibility to increase drug safety by preventive measures.
机译：目的：评估药物不良反应的发生和类型，以作为急性入院的原因。方法：在随机选择的681例患者中，他们被瑞典大学医院的内科诊所急诊收治，从他们的病历中收集了有关当前症状和药物使用，先前疾病以及医学调查和测试结果的信息。另外，根据调查表进行了标准化访问。一组临床药理学专家评估了从患者病例记录和访谈结果中获得的数据，然后根据WHO的标准，判断了药物不良反应可能导致或实际导致患者入院的可能性。医院。结果：在包括的681例病例中，有94例（13.8％）的症状和体征被判定为与药物有关，并已导致或促成入院。 82名患者（12.0％）共有99种症状被归类为药物不良反应。其中，91％是A型反应。药物与反应之间的关系被确定为八分之一，可能为十七分，可能为74例。最常见的药物不良反应是心血管（36.3％）。 12名患者（1.8％）出现中毒症状。结论：引起或促使进入内科诊所的药物相关问题的患病率很高，且以A型反应为主，即原则上可预测和可预防的反应。这意味着可以通过预防措施提高药物安全性。

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