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首页> 外文期刊>Pharmacoepidemiology and drug safety >Agreement between patient self-report and a Veterans Affairs national pharmacy database for identifying recent exposures to antibiotics.
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Agreement between patient self-report and a Veterans Affairs national pharmacy database for identifying recent exposures to antibiotics.

机译：患者自我报告与退伍军人事务国家药房数据库之间的协议，用于确定近期对抗生素的接触。

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PURPOSE: The dramatic rise in antibiotic drug resistance among community pathogens has stimulated interest in the epidemiological relationship between antibiotic exposure and drug resistance. In assessing the strength of this relationship, studies are hampered by the lack of data on the accuracy of subject self-report of antibiotic exposure. The authors compared self-report with pharmacy dispensing data to determine the accuracy of self-reported antibiotic exposure. METHODS: The study design was a cross-sectional survey of veterans seen at the Philadelphia Veterans Affairs (VA) Medical Center in 1999 and 2000. Subjects reported exposures to antibiotics, antihypertensive drugs and nonsteroidal anti-inflammatory drugs through a structured telephone interview. The instrument included open-ended questions, condition-specific prompts and drug-specific prompts. Subject responses were linked to a national VA pharmacy database that served as the reference standard for evaluating self-reported exposures. RESULTS: The authors found that the sensitivity of self-report of antibiotic exposure increased with increasing use of prompts. A comprehensive assessment of antibiotic exposure identified 73% of antibiotic exposures, compared to 73% of antihypertensive drug exposures and 92% of nonsteroidal anti-inflammatory drug exposures. CONCLUSIONS: Assessment of antibiotic exposure appears to be comparable to assessment of other chronic and episodic drugs. Multistep assessment of exposure improves the sensitivity of assessment.
机译：目的：社区病原体中抗生素耐药性的急剧上升激发了人们对抗生素暴露与耐药性之间流行病学关系的兴趣。在评估这种关系的强度时，由于缺乏关于受试者自我报告抗生素暴露的准确性的数据而阻碍了研究。作者将自我报告与药房配药数据进行了比较，以确定自我报告的抗生素暴露的准确性。方法：该研究设计是对1999年和2000年在费城退伍军人事务（VA）医疗中心看过的退伍军人的横断面调查。受试者通过结构化电话采访报告了抗生素，抗高血压药和非甾体类抗炎药的暴露情况。该工具包括开放式问题，针对具体病情的提示和针对特定药物的提示。受试者的反应与国家VA药房数据库链接，该数据库用作评估自我报告的暴露水平的参考标准。结果：作者发现，随着使用提示的增加，自我报告抗生素暴露的敏感性增加。抗生素暴露的综合评估确定了73％的抗生素暴露，而73％的降压药物暴露和92％的非甾体类抗炎药物暴露。结论：对抗生素接触的评估似乎与对其他慢性和发作性药物的评估具有可比性。暴露的多步评估可提高评估的敏感性。

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