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首页> 外文期刊>Pharmacogenetics >Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population.
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Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population.

机译：黎巴嫩人群中的芳胺N-乙酰基转移酶1（NAT1）基因型。

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摘要

The frequency distributions of human N-acetyltransferase 1 (NAT1*) alleles in various ethnic groups are largely unknown. This lack of information is in contrast to the many studies of ethnic differences in NAT2* alleles and phenotypes. Increasing interest in NAT1 due to its potential roles in carcinogen metabolism and cancer risk makes it desirable to know the distribution of NAT1* alleles in various populations. Using a polymerase chain reaction-restriction fragment length polymorphism genotyping assay, the frequency of NAT1* alleles in a Lebanese population was determined. Of 84 NAT1* alleles assayed, 56% were NAT1*4. Alleles NAT1*3, *10, and *14 were found at frequencies of 0.036, 0.107, and 0.238, respectively. Five additional alleles (6%) differed from previously reported alleles. Nearly 50% of the population were heterozygous for a NAT1*14 allele. The unusually high frequency of NAT1*14 alleles in Lebanese may be useful for epidemiological studies of the effects of the NAT1 polymorphism in this population.
机译：在各个种族中，人类N-乙酰基转移酶1（NAT1 *）等位基因的频率分布在很大程度上是未知的。缺乏信息与NAT2 *等位基因和表型的种族差异的许多研究形成对比。由于其在致癌物代谢和癌症风险中的潜在作用，人们对NAT1的兴趣日益增加，因此人们希望了解NAT1 *等位基因在不同人群中的分布。使用聚合酶链反应-限制性片段长度多态性基因分型测定法，确定了黎巴嫩人群中NAT1 *等位基因的频率。在分析的84个NAT1 *等位基因中，有56％是NAT1 * 4。发现等位基因NAT1 * 3，* 10和* 14的频率分别为0.036、0.107和0.238。另外五个等位基因（6％）与以前报道的等位基因不同。对于NAT1 * 14等位基因，近50％的人口是杂合的。黎巴嫩人中NAT1 * 14等位基因异常高的频率可能有助于对该人群中NAT1多态性的影响进行流行病学研究。

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