...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacogenetics >NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
【24h】

NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.

机译：NAD（P）H：醌氧化还原酶：高加索人，中国人和加拿大土著印度人和因纽特人群体中的多态性和等位基因频率。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

NAD(P)H:quinone oxidoreductase (NQO1) catalyses the two-electron reduction of quinone compounds. NQO1 is involved in the reductive bioactivation of cytotoxic antitumour quinones such as mitomycin C, but also plays a protective role against the carcinogenicity and mutagenicity of quinones, their precursors and metabolites. Three alleles have been identified in the human population: the functional Arg139/Pro187 allele (which we have termed NQO1*1); the nonfunctional allele Arg139/Ser187 (NQO1*2) and the Trp139/Pro187 allele (NQO1*3), which is associated with a diminished activity. We applied polymerase chain reaction-based genotyping assays to characterize interethnic variability in the frequency of NQO1 alleles in Caucasian (n = 575), Canadian Native Indian (n = 110), Canadian Inuit (n = 83) and Chinese (n = 86) populations. The NQO1*2 allele was found at significantly higher frequencies in Chinese (0.49) and Native North American populations (Inuit 0.46; Canadian Native Indians 0.40) compared with Caucasians (0.16). The NQO1*3 allele was not observed in Inuit individuals, and occurred at a lower frequency than the NQO*2 allele in Caucasians (0.05), Chinese (0.04) and Canadian Native Indians (0.01). Our results predict that a greater proportion of Orientals and related ethnic groups lack, or have reduced, NQO activity relative to Caucasians. Affected individuals may not only exhibit resistance to quinone-based cancer therapy because of a decreased production of cytotoxic drug metabolites, but may also be more susceptible to toxicities associated with toxicants.
机译：NAD（P）H：醌氧化还原酶（NQO1）催化醌化合物的双电子还原。 NQO1参与细胞毒性抗肿瘤醌（如丝裂霉素C）的还原性生物活化，但对醌，其前体和代谢物的致癌性和致突变性也起保护作用。在人群中已鉴定出三个等位基因：功能性Arg139 / Pro187等位基因（我们称为NQO1 * 1）;非功能性等位基因Arg139 / Ser187（NQO1 * 2）和Trp139 / Pro187等位基因（NQO1 * 3），它们的活性降低。我们应用了基于聚合酶链反应的基因分型分析方法，以表征白种人（n = 575），加拿大土著印度人（n = 110），加拿大因纽特人（n = 83）和中国人（n = 86）中NQO1等位基因频率的种族差异。人口。与白种人（0.16）相比，在中国（0.49）和北美原住民（因纽特人（inuit）0.46;加拿大土著印第安人0.40）中发现NQO1 * 2等位基因的频率明显更高。在因纽特人个体中未观察到NQO1 * 3等位基因，并且在白种人（0.05），中国人（0.04）和加拿大土著印第安人（0.01）中发生的频率低于NQO * 2等位基因。我们的结果预测，与高加索人相比，更多的东方人和相关种族缺乏或减少了NQO活动。由于细胞毒性药物代谢产物的产生减少，受影响的个体不仅可能表现出对基于醌的癌症治疗的抗性，而且可能更容易受到与毒性物质有关的毒性的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号