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PharmGKB summary: very important pharmacogene information for CYP1A2.

机译:PharmGKB摘要:CYP1A2的非常重要的药物基因信息。

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摘要

CYP1A2 is part of the cytochrome P450 (GYP) family of drug-metabolizing enzymes. The CYP1A2 gene is found in a cluster with CYP1A1 and CYP1B1 on chromosome 15 [1]. CYP1A2 and CYP1A1 share a 5'-flanking region of approximately 23 kb, which contains shared regulatory elements, although the genes are positioned back to back and transcription occurs in opposite directions [2]. The CYP1A2 gene spans around 7.8 kb and features seven exons and six introns, the first being a 55-bp-long noncoding exon. CYP1A2 is a 515-residue protein with a molecular mass of 58 294 Da [1].
机译:CYP1A2是药物代谢酶的细胞色素P450(GYP)家族的一部分。 CYP1A2基因在15号染色体上与CYP1A1和CYP1B1簇存在[1]。 CYP1A2和CYP1A1共享一个约23 kb的5'侧翼区域,其中包含共享的调控元件,尽管这些基因背对背放置且转录方向相反[2]。 CYP1A2基因跨度约7.8 kb,具有七个外显子和六个内含子,第一个是55 bp长的非编码外显子。 CYP1A2是一种515残基的蛋白质,分子量为58 294 Da [1]。

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