• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacogenetics and genomics >Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
【24h】

Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.

机译：异种代谢基因变异，农药使用和前列腺癌的风险。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: To explore associations with prostate cancer and farming, it is important to investigate the relationship between pesticide use and single nucleotide polymorphisms (SNPs) in xenobiotic metabolic enzyme (XME) genes. OBECTIVE: We evaluated pesticide-SNP interactions between 45 pesticides and 1913 XME SNPs with respect to prostrate cancer among 776 cases and 1444 controls in the Agricultural Health Study. METHODS: We used unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Multiplicative SNP-pesticide interactions were calculated using a likelihood ratio test. RESULTS: A positive monotonic interaction was observed between petroleum oil/petroleum distillate use and rs1883633 in the oxidative stress gene glutamate cysteine ligase (GCLC; P interaction=1.0x10(-4)); men carrying at least one variant allele (minor allele) experienced an increased prostate cancer risk (OR=3.7, 95% CI: 1.9-7.3). Among men carrying the variant allele for thioredoxin reductase 2 (TXNRD2) rs4485648, microsomal epoxide hydrolase 1 (EPHX1) rs17309872, or myeloperoxidase (MPO) rs11079344, an increased prostate cancer risk was observed with high, compared with no, petroleum oil/petroleum distillate (OR=1.9, 95% CI: 1.1-3.2, P interaction=0.01; OR=2.1, 95% CI: 1.1-4.0, P interaction=0.01), or terbufos (OR=3.0, 95% CI: 1.5-6.0, P interaction=2.0x10(-3)) use, respectively. No interactions were deemed noteworthy at the false discovery rate=0.20 level; the number of observed interactions in XMEs was comparable with the number expected by chance alone. CONCLUSION: We observed several pesticide-SNP interactions in oxidative stress and phase I/II enzyme genes and risk of prostate cancer. Additional work is needed to explain the joint contribution of genetic variation in XMEs, pesticide use, and prostate cancer risk.
机译：背景：探讨与前列腺癌和农业的关系，研究农药使用与异种代谢酶（XME）基因中的单核苷酸多态性（SNP）之间的关系非常重要。目的：在农业健康研究中，我们评估了776例病例和1444例对照中45种农药与1913种XME SNP之间的农药-SNP相互作用对前列腺癌的影响。方法：我们使用无条件逻辑回归来估计比值比（OR）和95％置信区间（CI）。使用似然比检验计算乘性SNP-农药相互作用。结果：在氧化应激基因谷氨酸半胱氨酸连接酶（GCLC; P相互作用= 1.0x10（-4））中，石油/石油馏出物的使用与rs1883633之间存在正单调相互作用。携带至少一个变异等位基因（次要等位基因）的男性患前列腺癌的风险增加（OR = 3.7，95％CI：1.9-7.3）。在携带硫氧还蛋白还原酶2（TXNRD2）rs4485648，微粒体环氧化物水解酶1（EPHX1）rs17309872或髓过氧化物酶（MPO）rs11079344的变异等位基因的男性中，与没有石油/石油馏出液相比，前列腺癌的患病风险高。 （OR = 1.9，95％CI：1.1-3.2，P相互作用= 0.01; OR = 2.1，95％CI：1.1-4.0，P相互作用= 0.01）或terbufos（OR = 3.0，95％CI：1.5-6.0 ，分别使用P互动= 2.0x10（-3））。在错误发现率= 0.20的水平上，没有交互被认为值得注意。在XME中观察到的交互作用的数量与仅凭偶然而预期的数量是可比的。结论：我们在氧化应激和I / II期酶基因和前列腺癌的风险中观察到几种农药-SNP相互作用。需要进一步的工作来解释XME中遗传变异，农药使用和前列腺癌风险的共同贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号