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首页> 外文期刊>Physiology & behavior >Enhancement of the acoustic startle reflex by an alarm pheromone in male rats.
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Enhancement of the acoustic startle reflex by an alarm pheromone in male rats.

机译：警报信息素增强雄性大鼠的听觉惊吓反射。

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Recently, we reported that an alarm pheromone released from the perianal region of male rats aggravated stress-induced hyperthermia and increased defensive and risk assessment behaviors in recipient male rats. Based on these results, we hypothesized that the primary effect of the alarm pheromone is to increase anxiety; however, there is still no clear evidence for this pheromone effect. Therefore, we examined this issue by assessing the effect of the alarm pheromone on the acoustic startle reflex (ASR), which is a useful index for studying negative emotions such as anxiety in rats. The alarm pheromone enhanced the ASR for 105-dB auditory stimuli, but not for those of 90 and 120 dB, when these three intensities of sound were used randomly. The same results were obtained when one of these three intensities was used repeatedly. In addition, pretreatment with diazepam (i.p.) at doses of 0.7 and 2.0 mg/kg suppressed the ASR of the pheromone recipients, whereas the lower dose (0.2 mg/kg) slightly attenuated the pheromone effect and the control injection (vehicle) had no effect. These results indicate that the alarm pheromone enhances the ASR by increasing anxiety in recipient rats, suggesting that the primary effect of the alarm pheromone is to increase the anxiety level.
机译：最近，我们报道了雄性大鼠肛周区域释放的一种信息素加剧了应激诱导的体温过高，并增加了雄性大鼠的防御和风险评估行为。根据这些结果，我们假设警报信息素的主要作用是增加焦虑。然而，仍然没有明确的证据证明这种信息素的作用。因此，我们通过评估警报信息素对听觉惊吓反射（ASR）的作用来研究此问题，这是研究大鼠焦虑等负面情绪的有用指标。当随机使用这三种强度的声音时，警报信息素可增强105 dB听觉刺激的ASR，但不能增强90 dB和120 dB听觉刺激的ASR。重复使用这三种强度之一可获得相同的结果。此外，以0.7和2.0 mg / kg的地西epa（ip）预处理可抑制信息素受体的ASR，而较低的剂量（0.2 mg / kg）则稍微减弱了信息素的作用，而对照注射剂（载体）没有影响。这些结果表明，警报信息素通过增加受体大鼠的焦虑来增强ASR，这表明警报信息素的主要作用是增加焦虑水平。

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