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首页> 外文期刊>Physiology & behavior >Acute tolerance to rate-decreasing effects of single doses of ethanol.
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Acute tolerance to rate-decreasing effects of single doses of ethanol.

机译：急性耐受单剂量乙醇的降速作用。

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Acute tolerance occurs when behavioral impairment is greater at a given blood ethanol concentration (BAC) on the ascending versus descending limb of the BAC-time curve following administration of a single dose of ethanol, however studies utilizing learned behaviors have not been widely reported. We assessed acute tolerance to single doses of ethanol in five Lewis rats responding under a fixed-ratio (FR8) schedule of food presentation. Response rates for food during 1-min components (ending 2, 4, 11, 18, 33, and 57 min after ethanol administration) were determined, and BAC was measured immediately after each component using a rat breathalyzer. Ethanol (0.4, 0.6, 0.8, and 1.2 g/kg, i.p.) produced dose-related decreases in responding for food that tended to recover over time for all but the highest dose tested. Similarly, dose-related increases in BAC were also observed. Using either an analysis that expressed impairment per unit BAC on the ascending limb versus the descending limb (by assessing the area under the curve (AUC) for behavior and BAC on each limb), the slope of the function that relates the behavioral effect to BAC (each expressed as percent maximum effect), or a variant of the Mellanby method (hysteresis), acute tolerance was observed following a dose of 0.4 g/kg ethanol. Though behavior appeared to recover on the descending limb following higher doses (especially 0.6 and 0.8 g/kg), acute tolerance to these doses was not present.
机译：在给定血液乙醇浓度（BAC）的情况下，单次服用乙醇后，行为在BAC时间曲线的上升与下降曲线上表现出更大的行为时，就会出现急性耐受，但是尚未广泛报道利用学习的行为进行的研究。我们评估了五只Lewis老鼠对单剂量乙醇的急性耐受，这五只老鼠按固定比例（FR8）的食物提示时间表做出反应。确定了在1分钟成分中（给予乙醇后2、4、11、18、33和57分钟）食品的响应率，并在使用了大鼠呼吸测定仪的每种成分后立即测量了BAC。乙醇（0.4、0.6、0.8和1.2 g / kg，腹膜内）对食物的响应引起剂量相关的下降，除了最高测试剂量外，其他所有食物都有随时间恢复的趋势。同样，也观察到BAC剂量相关的增加。使用表示上升的肢体与下降的肢体的每单位BAC损伤的分析（通过评估行为和BAC的曲线下面积（AUC）和每条肢体的BAC），将行为效应与BAC相关的功能斜率（以最大作用百分比表示）或Mellanby方法的一种变体（磁滞），在剂量为0.4 g / kg乙醇后观察到急性耐受性。尽管在较高剂量（特别是0.6和0.8 g / kg）下下降的肢体行为似乎恢复，但是对这些剂量没有急性耐受性。

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