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首页> 外文期刊>Physiology & behavior >Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama).
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Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama).

机译：5-羟色胺受体促成P. olacoides（Marapuama）的促记忆作用。

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摘要

Nootropic, antioxidant, and neuroprotective properties have been shown in a standardized ethanol extract of Ptychopetalum olacoides (POEE), a medicinal plant traditionally used by the Amazonian elderly population. It has been revealed that POEE mechanisms of action include anticholinesterase effects, and involve beta-adrenergic and dopamine D(1) receptors. The purpose of this study was to verify the role of serotonin receptors in the promnesic effects of this standardized extract. The step-down task in mice and selective serotonin antagonists were used. The study reveals that POEE promnesic effects on short-term (acquisition, consolidation and retrieval) and long-term (retrieval) declarative aversive memories are increased by 5HT(2A) (but not 5HT(1A)) serotonin antagonists (spiperone and pindolol, respectively). The observed synergism between POEE and spiperone can be interpreted as the combined effects of two subeffective doses of two 5HT antagonists, or the known synergism between an acetylcholinesterase inhibitor (POEE) and a 5HT antagonist. In conclusion it is suggested that 5HT(2A) serotonin receptors are relevant for the promnesic effects of this extract, adding to its multiple mechanisms of action.
机译：益智Ptychopetalum olacoides（POEE）的标准乙醇提取物已显示出促智，抗氧化剂和神经保护特性，该提取物是亚马逊老年人群传统上使用的药用植物。现已发现POEE的作用机制包括抗胆碱酯酶作用，并涉及β-肾上腺素能和多巴胺D（1）受体。这项研究的目的是验证5-羟色胺受体在这种标准化提取物的促记忆作用中的作用。使用了小鼠降压任务和选择性的5-羟色胺拮抗剂。该研究表明，5HT（2A）（而非5HT（1A））5-羟色胺拮抗剂（Spiperone和Pindolol，分别）。观察到的POEE和spiperone之间的协同作用可以解释为两种亚有效剂量的两种5HT拮抗剂的联合作用，或者是乙酰胆碱酯酶抑制剂（POEE）和5HT拮抗剂之间的已知协同作用。总之，建议5HT（2A）血清素受体与这种提取物的促记忆作用有关，从而增加了其多种作用机制。

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