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首页> 外文期刊>Physiology & behavior >Dissociation of the circadian rhythm of locomotor activity in a 22 h light-dark cycle impairs passive avoidance but not object recognition memory in rats.
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Dissociation of the circadian rhythm of locomotor activity in a 22 h light-dark cycle impairs passive avoidance but not object recognition memory in rats.

机译：在22小时的明暗周期中，运动活动的昼夜节律的解离会损害被动回避，但不会损害大鼠的对象识别记忆。

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摘要

We analyzed the effect of dissociation of the circadian rhythm of locomotor activity on the performance in two memory tasks in rats. One group of animals was maintained in a normal 24 h light-dark cycle of 12:12 (T24 group, control). A second group was housed in a 22 h cycle of 11:11 (T22 group, experimental), a condition which is known to produce dissociation of the circadian rhythm of locomotor activity in two components. Both groups were tested on two memory tasks: passive avoidance and object recognition. An additional control group, kept under constant darkness (DD group), was used for a passive avoidance task. Testing occurred 30 min (short-term memory--STM) and 24 h (T24 and DD group) or 22 h (T22 group) (long-term memory--LTM) after training. The T22 group showed impairment on the passive avoidance task (STM and LTM) compared with the T24 and DD groups. On the object recognition task, the T22 and T24 groups performed similarly in all the sessions. In conclusion, circadian rhythm dissociation induced a performance deficit in the passive avoidance task but had no effect on the object recognition task. We suggest that dissociation of the circadian rhythm of locomotor activity may selectively affect some emotional component related to fear and risk evaluation.
机译：我们分析了运动活动的昼夜节律的解离对大鼠在两个记忆任务中的表现的影响。一组动物维持在正常的24小时12:12的明暗循环中（T24组，对照）。第二组以11:11的22小时周期饲养（T22组，实验），这种情况已知会导致运动活动的昼夜节律解离为两个部分。两组都在两项记忆任务上进行了测试：被动回避和对象识别。另一个处于黑暗中的对照组（DD组）被用于被动回避任务。训练后30分钟（短期记忆-STM）和24小时（T24和DD组）或22小时（T22组）（长期记忆-LTM）进行测试。与T24和DD组相比，T22组在被动回避任务（STM和LTM）上表现出损伤。在对象识别任务上，T22和T24组在所有会话中的执行情况相似。总之，昼夜节律解离在被动回避任务中导致了性能缺陷，但对目标识别任务没有影响。我们建议运动活动的昼夜节律的分离可能会选择性地影响一些与恐惧和风险评估有关的情绪成分。

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