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首页> 外文期刊>Physiology & behavior >Peroxisome proliferator-activated receptors and the metabolic syndrome.
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Peroxisome proliferator-activated receptors and the metabolic syndrome.

机译：过氧化物酶体增殖物激活受体与代谢综合征。

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摘要

The prevalence of the metabolic syndrome is rapidly increasing. This syndrome is characterized by metabolic disturbances, such as abnormal lipid and carbohydrate metabolism and a low-grade inflammatory state. PPARs play an important role in these metabolic processes, which makes them effective targets for treatment and prevention of the metabolic syndrome. Synthetic PPAR agonists, such as fibrates and thiazolidinediones are already used to treat hyperlipidemia and diabetes mellitus, respectively. Besides synthetic ligands, dietary fatty acids and fatty acid derivatives can also bind to an activate PPARs. As demonstrated with ligand-binding assays, PPARs have a clear preference of binding polyunsaturated fatty acids. Monounsaturated fatty acids are also very effective in binding PPARs, whereas saturated fatty acids are poor PPAR binders. However, ligand binding does not necessarily mean transcriptional activation. Therefore, it is important to investigate transactivation properties of dietary fatty acids as PPAR agonists and their role in metabolic reactions. Furthermore, human intervention studies comparing the effects of natural versus synthetic ligands side-by-side may reveal specific fatty acids that exert beneficial PPAR-mediated metabolic effects. The ability of PPARs to sense fatty acids and to mediate lipid metabolism, glucose metabolism and the inflammatory state makes them excellent targets for dietary modulation in order to prevent and treat the metabolic syndrome and associated diseases. This review discusses the role and function of PPARs and their ligands in light of the metabolic syndrome.
机译：代谢综合征的患病率迅速增加。该综合征的特征是代谢紊乱，例如异常的脂质和碳水化合物代谢以及低度的炎症状态。 PPAR在这些代谢过程中起着重要作用，这使其成为治疗和预防代谢综合征的有效靶点。合成的PPAR激动剂，例如贝特类和噻唑烷二酮类，已经分别用于治疗高脂血症和糖尿病。除合成配体外，膳食脂肪酸和脂肪酸衍生物还可与活化的PPAR结合。如配体结合测定所证明的，PPAR具有结合多不饱和脂肪酸的明显偏好。单不饱和脂肪酸在结合PPAR方面也非常有效，而饱和脂肪酸则是不良的PPAR粘合剂。但是，配体结合并不一定意味着转录激活。因此，重要的是研究膳食脂肪酸作为PPAR激动剂的反式激活特性及其在代谢反应中的作用。此外，人类干预研究并排比较了天然配体和合成配体的作用，可能揭示了发挥有益PPAR介导的代谢作用的特定脂肪酸。 PPAR感知脂肪酸并介导脂质代谢，葡萄糖代谢和炎症状态的能力使它们成为预防和治疗代谢综合征和相关疾病的饮食调节的极佳靶标。这篇综述根据代谢综合征讨论了PPAR及其配体的作用和功能。

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