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首页> 外文期刊>Physiology & behavior >Analysis of motor function and dopamine systems of SAMP6 mouse.
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Analysis of motor function and dopamine systems of SAMP6 mouse.

机译：SAMP6小鼠的运动功能和多巴胺系统分析。

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摘要

The motor function of senescence-accelerated mouse prone 6 (SAMP6) was evaluated with a battery of behavioral tests: locomotor activity test, traction test, wire hanging test, and rotating rod test. SAMP6 exhibited increased locomotor activity compared with senescence-accelerated mouse resistant 1 (SAMR1). There was no difference between SAMP6 and SAMR1 in the traction and wire hanging tests. In the rotating rod test, shorter retention times at each day in the accelerating version of the test were observed in SAMP6 compared with SAMR1, indicating a motor coordination deficit of SAMP6. To understand the mechanism involved, we focused on the dopamine system. Measurement of dopamine and its metabolites with HPLC revealed that the concentrations of dopamine in nucleus accumbens (NAcs) and cerebellum and of one or more dopamine metabolites in all tissues assayed were significantly higher in SAMP6 compared with SAMR1. Increases of dopamine transporter and dopamine receptor 1 (D1) in striatum, of dopamine receptor 3 (D3) in NAc, and of D1 and D3 in cerebellum in SAMP6 were observed. These results indicate that increased dopamine concentration in NAc and increased expression of D1 in striatum are possible cause(s) of the increased locomotor activity of SAMP6, and that increased D3 expression in cerebellum contributes to the motor coordination deficit of SAMP6.
机译：通过一系列行为测试来评估衰老加速小鼠俯卧6（SAMP6）的运动功能：运动能力测试，牵引力测试，电线悬挂测试和旋转杆测试。与衰老加速的小鼠抗药性1（SAMR1）相比，SAMP6表现出更高的运动活性。 SAMP6和SAMR1在牵引力和电线悬挂测试中没有差异。在旋转棒测试中，与SAMR1相比，SAMP6在加速测试中每天的保留时间短，这表明SAMP6的运动协调能力不足。为了了解所涉及的机制，我们集中于多巴胺系统。用HPLC测量多巴胺及其代谢物表明，在被测的所有组织中伏隔核（NAcs）和小脑中多巴胺的浓度以及一种或多种多巴胺代谢物的浓度在SAMP6中均显着高于SAMR1。观察到纹状体中多巴胺转运蛋白和多巴胺受体1（D1），NAc中多巴胺受体3（D3）以及SAMP6中小脑中D1和D3的增加。这些结果表明，NAc中多巴胺浓度的增加和纹状体中D1表达的增加可能是SAMP6运动活性增加的原因，而小脑中D3表达的增加是SAMP6运动协调性不足的原因。

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