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首页> 外文期刊>Physiology & behavior >Spontaneous movements: Effect of denervation and relation to the adaptation of nociceptive withdrawal reflexes in the rat.
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Spontaneous movements: Effect of denervation and relation to the adaptation of nociceptive withdrawal reflexes in the rat.

机译：自发运动：去神经作用及其与伤害性退缩反射适应的关系。

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Spontaneous movements are a ubiquitous phenomenon during development. Recently, we demonstrated that these movements play a key role in the functional adaptation of spinal reflex circuits. Here, we analyse the role of afferent input in the generation of spontaneous movements and characterize the occurrence of different types of spontaneous movements and their relation to the functional adaptation of the nociceptive withdrawal reflexes (NWR) up to postnatal day 22 (P22). Noxious thermal stimulation was used to evoke reflex responses in awake rats. Spontaneous tail movements occurring during active sleep were counted during the first three postnatal weeks and classified into two major classes: simple movements (unidirectional) and complex twitches (bi-directional and oscillating). All spinal nerves caudal to L2 were cut at P12 to study the effect of deafferentation on spontaneous movements. The number of simple movements and complex twitches in the deafferented animals did not differ as compared to control animals. The adaptation of tail NWR occurred during the period P7-P22. Spontaneous tail movements occurred relatively frequently and overlapped in time the adaptation of NWR. Notably, the relative number of simple movements increased in parallel with the functional adaptation of the NWR, suggesting a role of simple twitches in NWR adaptation. The present findings indicate that the spontaneous movements studied are driven by intrinsic mechanisms in the CNS and suggest that sensory feedback does not influence the spontaneous movement patterns. Moreover, the NWR adaptation appears to be related to a qualitative change in spontaneous movements caused by maturation in spinal reflex circuit connections.
机译：自发运动是发育过程中普遍存在的现象。最近，我们证明了这些运动在脊柱反射回路的功能适应中起着关键作用。在这里，我们分析传入输入在自发运动产生中的作用，并描述了不同类型的自发运动的发生及其与伤害性退缩反射（NWR）的功能适应性的关系，直到出生后第22天（P22）。有害的热刺激被用于唤醒清醒大鼠。在出生后的前三周内，对活跃睡眠中发生的自发尾巴运动进行了计数，并将其分为两大类：简单运动（单向）和复杂抽搐（双向和摆动）。在P12切开所有L2尾部的脊神经，以研究脱除力对自发运动的影响。与对照组动物相比，脱除力的动物中简单动作和复杂抽搐的次数没有差异。尾部NWR的适应发生在P7-P22期间。自发的尾巴运动相对频繁地发生，并且在适应NWR的时间上重叠。值得注意的是，简单动作的相对数量与NWR的功能调整同时增加，这表明简单抽搐在NWR调整中的作用。目前的发现表明，所研究的自发运动是由中枢神经系统内在机制驱动的，并且表明感觉反馈不影响自发运动模式。此外，NWR的适应性似乎与脊柱反射回路连接成熟引起的自发运动的质变有关。

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