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首页> 外文期刊>Physiology & behavior >Individual housing of mice--impact on behaviour and stress responses.
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Individual housing of mice--impact on behaviour and stress responses.

机译：单独安置小鼠-影响行为和压力反应。

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The replicability of results derived from studies in rodents might be influenced by stress caused by inappropriate housing conditions. Here we compared the experimental behaviour and stress response (circulating corticosterone level and adrenal tyrosine hydroxylase activity) of individually-housed male and female inbred mice with that of animals housed in social groups. All mice were behaviourally tested in the modified hole board test (mHB). Male C57BL/6, BALB/c and A mice housed in groups of 3 were compared with individually-housed mice. In a subsequent experiment female C57BL/6 and BALB/c mice were housed under similar conditions. To exclude the possible effects of within-cage order of testing, only one individual per group was behaviourally tested. Neither male nor female mice housed individually showed stronger signs of stress than their socially-housed counterparts. However, we observed a within-cage order effect on the hormonal stress response (corticosterone) in socially-housed female C57BL/6 mice. No effects of individual housing on behaviour in the mHB were found.
机译：在啮齿类动物研究中得出的结果的可复制性可能受到不合适的住房条件引起的压力的影响。在这里，我们比较了雌性和雌性近交小鼠与社会群体中动物的实验行为和应激反应（循环皮质酮水平和肾上腺酪氨酸羟化酶活性）。在改良的孔板试验（mHB）中对所有小鼠进行了行为测试。将3只一组的雄性C57BL / 6，BALB / c和A小鼠与单独饲养的小鼠进行比较。在随后的实验中，将雌性C57BL / 6和BALB / c小鼠饲养在相似的条件下。为了排除笼内测试顺序的可能影响，每组仅对一个人进行了行为测试。单独饲养的雄性和雌性小鼠都没有比在社会上饲养的雌性小鼠显示出更强的压力迹象。但是，我们观察到笼养对雌性C57BL / 6小鼠的荷尔蒙应激反应（皮质酮）的笼内顺序效应。没有发现个人住房对mHB行为的影响。

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