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首页> 外文期刊>Physiology & behavior >Heterogeneity of neuroendocrine stress responses in aging rat strains.
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Heterogeneity of neuroendocrine stress responses in aging rat strains.

机译：在衰老大鼠品系中神经内分泌应激反应的异质性。

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摘要

Hyperactivity of the hypothalamo-pituitary-adrenocortical (HPA) axis is linked with age-related decrements in cognition and neuronal survival. However, the nature and extent of age-related HPA axis deficits vary considerably across and indeed, within strains. The current study was designed to assess variance in HPA axis function using two rodent models commonly used in aging studies: Fischer 344 (F344) and F344/Brown-Norway F1 hybrid rats (F344/BN). We examined both basal and stress-induced ACTH and corticosterone (CORT) release in two stress contexts thought to differ in intensity: novel environment ('mild') and restraint ('intense'). Variability of the data was tested with a modification of the Brown-Forsythe test of homoscedasticity. The results indicated that F344 rats exhibit greater peak HPA responses. Furthermore, in most cases variability was increased in aged rats relative to young and middle-aged rats of the same strain, indicative of the emergence of individual differences in stress responsivity amongst older rats. The results suggest that these older rat strains may be useful models to further assess individual differences in neuroendocrine aging.
机译：下丘脑-垂体-肾上腺皮质（HPA）轴功能亢进与年龄和认知和神经元存活率下降有关。但是，与年龄相关的HPA轴缺陷的性质和程度在菌株之间乃至菌株之间差异很大。本研究旨在使用衰老研究中常用的两种啮齿动物模型来评估HPA轴功能的差异：Fischer 344（F344）和F344 / Brown-Norway F1杂交大鼠（F344 / BN）。我们在两种强度不同的应激环境中研究了基础和应激诱导的促肾上腺皮质激素和皮质酮（CORT）释放：新环境（轻度）和约束（强烈）。数据的变异性是通过对Brown-Forsythe均方差检验进行修改来检验的。结果表明F344大鼠表现出更高的峰值HPA反应。此外，在大多数情况下，相对于同一品系的年轻和中年大鼠，老年大鼠的变异性增加，这表明老年大鼠之间在应激反应性方面存在个体差异。结果表明，这些较老的大鼠品系可能是进一步评估神经内分泌衰老个体差异的有用模型。

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