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首页> 外文期刊>Physiology & behavior >Sexually dimorphic c-Fos expression following spatial working memory in young and adult rats.
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Sexually dimorphic c-Fos expression following spatial working memory in young and adult rats.

机译：年轻和成年大鼠空间工作记忆后的性二态性c-Fos表达。

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The sex differences in the functional contribution of brain substrates were explored following acquisition of a spatial working memory task using quantification of c-Fos protein. Rats of both sexes were trained during adolescence and adulthood in Morris water maze using a hidden escape platform with different daily location. Two control groups for each sex and age were added to explore the c-Fos activation not specific to the memory process. These were a free-swimming group (yoked control) and a handled control (CO) group. Behaviorally, no age differences were found in number of days required by males to acquire the task, but females showed a delay in acquisition during adolescence (P30) that improved in adulthood (P90). Both sexes showed a learning-related increase in Fos immunoreactivity in the anterodorsal and anteroventral thalamus and medial and lateral mammillary nuclei during adolescence. Higher levels of learning-related Fos immunoreactivity were found in the infralimbic cortex, CA3 and CA1 only in females. During adulthood the common activated region was the prelimbic cortex with the addition of the infralimbic cortex in the male group and the lateral mammillary nucleus in the female group. These results indicated sex and age differences in brain functioning following working memory task. However, they could not be necessarily linked with differences in performance since similar results were found between males and females during adulthood. The activation of common and interrelated structures suggests that these structures are involved in spatial processing but it also highlights the relevance of developmental changes for understanding the memory process.
机译：在使用c-Fos蛋白质定量获得空间工作记忆任务后，探讨了脑底物功能贡献的性别差异。在莫里斯水迷宫中，使用隐藏的逃生平台每天对不同性别的大鼠进行训练，这些平台的每日位置各不相同。为每个性别和年龄添加了两个对照组，以探索并非特定于记忆过程的c-Fos激活。这些是自由游泳的组（带轭的对照组）和处理的对照组（CO）组。从行为上看，男性完成任务所需的天数没有年龄差异，但是女性在青春期（P30）的获取延迟显示成年（P90）有所改善。青春期，男女在前庭和前腹丘脑以及内侧和外侧乳突核中均表现出与学习相关的Fos免疫反应性增加。与学习相关的Fos免疫反应性水平较高，仅在雌性下肢皮层，CA3和CA1中。在成年期间，男性的共同激活区域是前缘皮层，在女性组中增加了下缘皮层，而在女性组中则是外侧乳突核。这些结果表明工作记忆任务后大脑功能的性别和年龄差异。但是，由于成年期男性和女性之间的结果相似，因此不一定将它们与性能差异联系起来。共同和相互关联的结构的激活表明这些结构参与了空间处理，但同时也突出了发展变化与理解记忆过程的相关性。

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