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首页> 外文期刊>Physiology & behavior >Galanin-like peptide modulates energy balance by affecting inflammatory mediators?
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Galanin-like peptide modulates energy balance by affecting inflammatory mediators?

机译:甘丙肽样肽通过影响炎症介质来调节能量平衡?

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摘要

Galanin-like peptide (GALP) is a neuropeptide that is thought to play a role in the regulation of energy balance. However, the effects of GALP on food intake and body weight appear to be complex. In rats, central administration of GALP initially stimulates food intake, an effect that is followed by a reduction in food intake and body weight, whereas in mice, GALP has an anorectic action only. In rats and mice, GALP also causes a prostaglandin-dependent increase in core body temperature. These anorectic effects of GALP are similar to those observed after central administration of the pro-inflammatory cytokine interleukin-1 (IL-1). This review will discuss the evidence for the dichotomous actions of GALP on energy balance, and the potential mechanisms involved. I also describe a role for IL-1 in mediating the anorectic and febrile actions of GALP, and consider the possibility that GALP may act like an inflammatory mediator.
机译:甘丙肽样肽(GALP)是一种神经肽,被认为在调节能量平衡中起作用。但是,GALP对食物摄入和体重的影响似乎很复杂。在大鼠中,GALP的中央给药起初会刺激食物的摄入,随后是食物摄入量和体重的减少,而在小鼠中,GALP仅具有厌食作用。在大鼠和小鼠中,GALP还引起前列腺素依赖性核心体温升高。 GALP的这些厌食作用类似于集中施用促炎性细胞因子白介素-1(IL-1)后观察到的那些。这篇综述将讨论GALP在能量平衡方面的二分作用的证据,以及所涉及的潜在机制。我还描述了IL-1在介导GALP的厌食和发热作用中的作用,并考虑了GALP可能起炎症介质作用的可能性。

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