Protein microarrays: Challenges and promises

Talapatra A; Rouse R; Hardiman G

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Protein microarrays: Challenges and promises

机译：蛋白质微阵列：挑战与希望

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Genomics and proteomics are playing increasingly important roles as discovery tools in basic biological sciences and as diagnostic and rational therapeutic aids in the clinical arena. In recent years, high-density arrays of specified DNA sequences have gained popularity. Protein microarrays are at the forefront of this biochip revolution and promise the parallel examination of large numbers of proteins. These miniaturized arrays are currently being developed to facilitate high analytical resolution, detection sensitivity and sample throughput. Many challenges are presented by proteome scale manipulation of proteins, as there is currently no methodological equivalent to the gene chip for comparative proteomics.

机译：基因组学和蛋白质组学在基础生物学中的发现工具以及在临床领域中作为诊断和合理治疗手段的作用日益重要。近年来，特定DNA序列的高密度阵列已获得普及。蛋白质微阵列处于生物芯片革命的最前沿，并有望对大量蛋白质进行并行检查。目前正在开发这些小型阵列，以促进高分析分辨率，检测灵敏度和样品通量。蛋白质组学规模的蛋白质操作带来了许多挑战，因为目前尚无与比较蛋白质组学基因芯片相对应的方法论。

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来源
《Pharmacogenomics》 |2002年第4期|共10页
作者
Talapatra A; Rouse R; Hardiman G;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
protein analysis; protein microarray;

机译：蛋白质分析;蛋白质芯片;

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专利

1. Protein microarrays: Challenges and promises [J] . Talapatra A, Rouse R, Hardiman G Pharmacogenomics . 2002,第4期

机译：蛋白质微阵列：挑战与希望
2. Quality versus accuracy: result of a reanalysis of protein-binding microarrays from the DREAM5 challenge by using BayesPI2 including dinucleotide interdependence [J] . Junbai Wang BMC Bioinformatics . 2014,第1期

机译：质量与准确性：通过使用双核苷酸相互依赖性的BayesPI2对DREAM5挑战进行蛋白结合微阵列重新分析的结果
3. Facing Current Quantification Challenges in Protein Microarrays [J] . Robert Wellhausen Harald Seitz Journal of biomedicine & biotechnology . 2012,第8期

机译：面对蛋白质芯片中当前的定量挑战
4. Protein Microarray Applications and Future Challenges [C] . Thomas O. Joos International Forum on Biochip Technologies(IFBT 2004); 20041021-24; Beijing(CN) . 2004

机译：蛋白质微阵列应用和未来挑战
5. Development of multiplexed techniques using two-dimensional HPLC, protein microarrays and mass spectrometry for investigations in protein posttranslational modifications and disease progression pathways. [D] . Pal, Manoj. 2007

机译：使用二维HPLC，蛋白质微阵列和质谱技术研究蛋白质翻译后修饰和疾病进展途径的复合技术的发展。
6. Quality versus accuracy: result of a reanalysis of protein-binding microarrays from the DREAM5 challenge by using BayesPI2 including dinucleotide interdependence [O] . Junbai Wang 2014

机译：质量与准确性：通过使用双核苷酸相互依赖性的BayesPI2对DREAM5挑战进行蛋白结合微阵列重新分析的结果
7. Protein Microarrays as Tools for Functional Proteomics: Achievements, Promises and Challenges [O] . Smiths S Lueong 2014

机译：蛋白质微阵列作为功能性蛋白质组学的工具：成就，承诺和挑战
8. Development of a Chemoenzymatic-like and Photoswitchable Method for the High-Through put creation of Protein Microarrays. Application to the Analysis of the Protein/Protein Interactions Involved in the YOP Virulon from Yersinia pestis [R] . Camarero, J. A. 2007

机译：用于蛋白质微阵列的高通量创建的类化学酶和光可切换方法的开发。应用于鼠疫耶尔森氏菌YOp Virulon蛋白质/蛋白质相互作用的分析

Protein microarrays: Challenges and promises

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