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Pharmacogenetics in diverse ethnic populations - Implications for drug discovery and development

机译：不同种族人群的药物遗传学-对药物发现和开发的启示

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摘要

It is widely acknowledged that the vast quantities of data now publicly available as a result of the human genome initiative have the potential to revolutionize the pharmaceutical industry. More tangibly to the drug development business, the dawn of the pharmacogenetics era has the potential to impact not only the discovery of new medicines but also the safety and efficacy of pharmaceutical agents. Coincident with these scientific advances is the emergence of new markets for pharmaceutical agents. Japan, which represents the world's second biggest market, is a good example. With the ICH E5 agreement in 1998 and a rapid change in the drug registration process in Japan, there are increasing opportunities to improve access to more medicines in all parts of the world. However, it is increasingly clear that significant genetic variation still exists between populations, with a host of data on interethnic variation in drug metabolizing enzyme and drug transporter activity. Evidence suggesting that this genetic variation may play an important role in defining some of the interethnic variation in drug response to currently marketed compounds is reviewed here, and future possibilities of using such information to better streamline the drug development process are discussed.
机译：众所周知，由于人类基因组计划的结果，目前公开提供的大量数据具有革新制药业的潜力。对于药物开发业务而言，更切合实际的是，药物遗传学时代的到来不仅有可能影响新药的发现，而且还可能影响药剂的安全性和有效性。与这些科学进步相吻合的是出现了新的药剂市场。代表世界第二大市场的日本就是一个很好的例子。借助1998年的ICH E5协议以及日本药品注册流程的迅速变化，世界各地都有越来越多的机会来改善对更多药品的获取。但是，越来越明显的是，人群之间仍然存在显着的遗传变异，有关药物代谢酶和药物转运蛋白活性的种族间变异的数据很多。有证据表明，这种遗传变异可能在定义对当前市售化合物的药物反应的某些种族间变异中起重要作用，并讨论了使用此类信息更好地简化药物开发过程的未来可能性。

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