BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.

Rybakowski JK

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BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.

机译：BDNF基因：在情绪障碍和精神分裂症中具有功能性Val66Met多态性。

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The brain-derived neurotrophic factor (BDNF) gene has become a candidate gene for molecular-genetic studies of mood disorders and schizophrenia, and also for pharmacogenomics of drugs used in the treatment of these conditions, such as mood-stabilizers in bipolar mood disorder, antidepressants in depression, and antipsychotics in schizophrenia. It has been demonstrated that the functional Val66Met polymorphism of the gene can be associated with a number of clinical and pharmacological phenomena in these illnesses.

机译：脑源性神经营养因子（BDNF）基因已成为用于情绪障碍和精神分裂症的分子遗传学研究的候选基因，也已成为治疗这些疾病的药物的药物基因组学，例如双相情感障碍的情绪稳定剂，抗抑郁药和精神分裂症的抗精神病药。已经证明该基因的功能性Val66Met多态性可以与这些疾病中的许多临床和药理现象相关。

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《Pharmacogenomics》 |2008年第11期|共5页
作者
Rybakowski JK;
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正文语种 eng
中图分类药学;
关键词
Genes; Mood Disorders; Schizophrenia; Brain-Derived Neurotrophic Factor; 基因; 情绪障碍; 精神分裂症; 脑源性神经营养因子;

机译：Genes;Mood Disorders;Schizophrenia;Brain-Derived Neurotrophic Factor;基因;情绪障碍;精神分裂症;脑源性神经营养因子;

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1. BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. [J] . Rybakowski JK Pharmacogenomics . 2008,第11期

机译：BDNF基因：在情绪障碍和精神分裂症中具有功能性Val66Met多态性。
2. BDNF Variation and Mood Disorders: A Novel Functional Promoter Polymorphism and Val66Met are Associated with Anxiety but Have Opposing Effects [J] . Xueying Jiang, Ke Xu, Joelle Hoberman, Neuropsychopharmacology . 2005,第7期

机译：BDNF变异和情绪障碍：一种新型的功能启动子多态性和Val66Met与焦虑相关，但有相反的作用。
3. Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population. [J] . Suchanek R, Owczarek A, Kowalczyk M, Journal of Molecular Neuroscience: MN . 2011,第3期

机译：C-281A和BDNF基因val66met功能多态性与波兰人群复发性重度抑郁症风险之间的关联。
4. Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism [C] . Jinbo Fan, Pamela Skla Symposium on Growth Factors and Psychiatric Disorders . 2008

机译：双相障碍的遗传学：专注于BDNF Val66met多态性
5. The influence of BDNF Val66Met polymorphism on cognition, depression, quality of life, and motor symptoms in individuals with Parkinson's disease after dynamic cycling. [D] . Harper, Sara A. 2016

机译：BDNF Val66Met基因多态性对动态循环后帕金森氏病患者认知，抑郁，生活质量和运动症状的影响。
6. Identification of BDNF Sensitive Electrophysiological Markers of Synaptic Activity and Their Structural Correlates in Healthy Subjects Using a Genetic Approach Utilizing the Functional BDNF Val66Met Polymorphism [O] . Fruzsina Soltész, John Suckling, Phil Lawrence, -1

机译：使用功能性BDNF Val66Met多态性的遗传方法鉴定健康受试者中BDNF敏感突触活性的电生理标记及其结构相关性
7. BDNF Variation and Mood Disorders: A Novel Functional Promoter Polymorphism and Val66Met are Associated with Anxiety but Have Opposing Effects [O] . Xueying Jiang, Ke Xu, Joelle Hoberman, 2005

机译：BDNF变异和情绪障碍：一种新型功能促进剂多态性和Val66met与焦虑有关，但具有对抗影响

BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.

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