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首页> 外文期刊>Pharmacogenomics >Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation
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Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation

机译：同种异体造血干细胞移植患者中具有GSTA1多态性的白消安的群体药代动力学和药效学

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Aim: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. Patients & methods: A PPK model was developed from 36 patients by a one-compartment model with first-order elimination. Results: The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration-time curves (AUCs) increased with GSTA1 variants compared with wild-type (both p < 0.05). Subtherapeutic AUCs were seen only in wild-type patients. Conclusion: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK.
机译：目的：进行群体药代动力学（PPK）分析，以描述GSTA1基因多态性对接受异基因造血干细胞移植的成年人静脉内白消安的影响。患者与方法：采用一室消除一阶模型的36例患者开发了PPK模型。结果：清除率和分配量的典型值分别为11.0 l / h和42.4 l。与野生型相比，GSTA1变体的清除率降低了15％，在浓度-时间曲线下的面积（AUC）增加了（均p <0.05）。亚治疗型AUC仅在野生型患者中观察到。结论：据我们所知，这是第一项表明成人中GSTA1多态性与白消安PK相关的PPK研究。

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