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MDR1 gene polymorphisms and imatinib response in chronic myeloid leukemia: a meta-analysis

机译：慢性粒细胞白血病MDR1基因多态性与伊马替尼反应：一项荟萃分析

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Background:MDR1 gene polymorphisms were demonstrated to be associated with interindividual variability of imatinib response for chronic myeloid leukemia (CML) patients in several studies; however, the results have been inconclusive. Materials & methods: To clarify the effect of common MDR1 variants on clinical response to imatinib, we performed a meta-analysis to quantify the accumulated information from genetic association studies. After a thorough search of the published literature, we undertook a meta-analysis to evaluate the effect of MDR1 C1236T, G2677T and C3435T polymorphisms on imatinib response. Results: Our pooled data showed a significant association between MDR1 C1236T polymorphism and the increasing risk of imatinib resistance in Asian CML patients. However, no significant association was found for the MDR1 G2677T or C3435T polymorphisms in an Asian CML population as well as a Caucasian CML population. Conclusion: The synonymous MDR1 C1236T polymorphism might be a risk factor for nonoptimal clinical response to imatinib in Asian CML patients. Original submitted 19 August 2013; Revision submitted 10 January 2014
机译：背景：在多项研究中，MDR1基因多态性与慢性骨髓性白血病（CML）患者的伊马替尼反应个体间差异有关;但是，结果尚无定论。材料与方法：为了阐明常见的MDR1变体对伊马替尼临床反应的影响，我们进行了荟萃分析以量化遗传关联研究中积累的信息。在对已发表文献进行彻底搜索之后，我们进行了荟萃分析，以评估MDR1 C1236T，G2677T和C3435T多态性对伊马替尼反应的影响。结果：我们的汇总数据显示，亚洲CML患者的MDR1 C1236T多态性与伊马替尼耐药性增加的风险之间存在显着相关性。但是，在亚洲CML人群和白种人CML人群中，没有发现MDR1 G2677T或C3435T多态性的显着关联。结论：同义的MDR1 C1236T多态性可能是亚洲CML患者对伊马替尼非最佳临床反应的危险因素。原件于2013年8月19日提交;修订版于2014年1月10日提交

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