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首页> 外文期刊>Pharmacogenomics >New trends in pharmacogenomic strategies against resistance development in microbial infections.
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New trends in pharmacogenomic strategies against resistance development in microbial infections.

机译：针对微生物感染耐药性发展的药物基因组学策略的新趋势。

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摘要

This review summarizes some of the new trends in the fight against drug resistant bacteria. We review Gram-positive (e.g., S.aureus) and Gram-negative (e.g., Pseudomonas aeruginosa, Helicobacter pylori) bacteria, the current antibiotic resistance situation, as well as resistance spread and some recently discovered resistance mechanisms, such as those based on integrons and complex transposons. We then summarize several current routes to identify new drugs such as cationic antimicrobial peptides, novel acyldepsipeptides, RNA aptamers and lipopeptides. New drug strategies to treat resistant pathogens include eliciting growth in dormant bacteria, or a new way to attack efflux systems. Typical approaches from pharmacogenomics combined with systems biology and bioinformatics support these routes (simulations, metagenomics and metabolic network modeling), as well as the patient treatment (e.g., haplotyping and immune response).
机译：这篇综述总结了抗药性细菌斗争中的一些新趋势。我们回顾了革兰氏阳性（例如金黄色葡萄球菌）和革兰氏阴性（例如铜绿假单胞菌，幽门螺杆菌）细菌，当前的抗生素耐药性状况以及耐药性传播和一些最近发现的耐药机制，例如基于整合素和复杂的转座子。然后，我们总结了几种目前的途径，以鉴定新药，例如阳离子抗微生物肽，新型酰基糖肽，RNA适体和脂肽。治疗抗药性病原体的新药物策略包括引起休眠细菌的生长，或攻击外排系统的新方法。药物基因组学与系统生物学和生物信息学相结合的典型方法支持这些途径（模拟，宏基因组学和代谢网络建模）以及患者治疗（例如单体型和免疫反应）。

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