A predictive model for efavirenz dosing.

Brown C; Motsinger Reif AA

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A predictive model for efavirenz dosing.

机译：依非韦伦剂量的预测模型。

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High interindividual variability in efa-virenz (EFV) sensitivity [1] has been suggested as a cause for difficulty establishing correct dosage in HIV therapy, which is necessary in reducing toxicity while maintaining efficacy [2,3]. Although genetic variants have been associated with patient sensitivities in some populations [4], additional work is needed to solidly elucidate the physiological basis of these sensitivities. The current study helps fulfill this need through pharmacoki-netic/pharmacogenetic modeling of EFV plasma concentrations within a clinical population [5].

机译：有人认为，efa-virenz（EFV）敏感性的个体差异高[1]，这是在HIV治疗中难以确定正确剂量的原因，这对于降低毒性同时保持疗效[2,3]是必要的。尽管在某些人群中遗传变异与患者的敏感性有关[4]，但仍需要进一步的工作来扎实地阐明这些敏感性的生理基础。当前的研究通过临床人群中EFV血浆浓度的药代动力学/药物遗传学建模来帮助满足这一需求[5]。

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《Pharmacogenomics》 |2012年第2期|共2页
作者
Brown C; Motsinger Reif AA;
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正文语种 eng
中图分类药学;
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1. A predictive model for efavirenz dosing. [J] . Brown C, Motsinger Reif AA Pharmacogenomics . 2012,第2期

机译：依非韦伦剂量的预测模型。
2. Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing. [J] . Drusano GL, OL.COM, Preston SL, Antimicrobial agents and chemotherapy. . 2001,第7期

机译：在流感致死性鼠模型中，新型神经氨酸酶抑制剂RWJ-270201的药效学评估可预测每日给药的有效性。
3. A Population Pharmacokinetic/Pharmacodynamic Model Predicts Favorable HDL Cholesterol Changes Over the First 5 Years in Children Treated With Current Efavirenz-Based Regimens [J] . Homkham Nontiya, Cressey Tim R., Ingsrisawang Lily, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2016,第9期

机译：人口药代动力学/药效学模型预测了目前基于依非韦伦的方案治疗的儿童头5年HDL胆固醇的有利变化
4. Controllability of the Predictive Model and its Effect on the Stability of the Model Predictive Predictive controller [C] . The 7th World Congress on Intelligent Control and Automation(WCICA'08)(第七届智能控制与自动化世界大会)论文集 . 2008

机译：预测模型的可控制性及其对模型预测控制器稳定性的影响
5. Clinical predictive value of pre-clinical cancer models: A study of the predictive value of the in vitro cell line, human xenograft and murine allograft pre-clinical cancer models for phase II clinical trials of cytotoxic cancer drugs [D] . Voskoglou-Nomikos, Theodora 2001

机译：临床前癌症模型的临床预测价值：体外细胞系，人异种移植和小鼠同种异体移植临床前癌症模型对细胞毒性癌症药物II期临床试验的预测价值研究
6. CYP2B6*6 CYP2B6*18 Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe [O] . Milcah Dhoro, Simbarashe Zvada, Bernard Ngara, 2015

机译：CYP2B6 * 6CYP2B6 * 18体重和性别是efavirenz药代动力学和治疗反应的预测指标：津巴布韦HIV / AIDS和TB队列中的人群药代动力学模型
7. C, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe [O] . 2015

机译：C，体重和性别是依非韦伦药代动力学和治疗反应的预测指标：津巴布韦艾滋病毒/艾滋病和结核病队列中的人群药代动力学模型

A predictive model for efavirenz dosing.

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