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Pharmacogenomic considerations for immunosuppressive therapy.

机译：免疫抑制治疗的药物基因组学考虑。

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Immunosuppression, the art of suppressing the endogenous immune system to allow organ transplantation or treatment of autoimmune disease, is a clinico-pharmacological field that has markedly developed over the past three decades with the advent of highly potent and rationally targeted immunosuppressive agents. Pharmacogenomics, the art of providing tailored pharmacological therapy with the highest therapeutic index based on the genomic composition of the individual, is a science that has rapidly developed over the past decade, along with the advances in the human genome project and in biotechnology. Pharmacogenomics of immunosuppression is the combined art of tailoring specific immunosuppressive drug therapy to specific immune-mediated clinical entities which require immunosuppression, with optimum matching of the drug to the individual's genomic makeup. Timely and judicious application of pharmacogenomics to clinical immunosuppression should direct the clinician to the best immunosuppressive drug for any given clinical condition, and markedly increase its efficacy as well as decreasing the incidence of side effects and toxicity, thereby decreasing morbidity and prolonging survival. Is this a description of an ongoing clinical evolution in immunosuppression or a prediction of future events? The promises of pharmacogenomics of immunosuppression are high, yet the availability and/or application and/or realization of the promises of this highly specialized clinical science are very slow to come.
机译：免疫抑制是一种抑制内源性免疫系统以允许器官移植或治疗自身免疫性疾病的技术，它是一种临床药理学领域，在过去的三十年中，随着高效和合理靶向的免疫抑制剂的出现，该领域已显着发展。药理基因组学是一种基于个体的基因组组成提供具有最高治疗指数的量身定制药理疗法的技术，是随着人类基因组计划和生物技术的发展在过去十年中迅速发展的一门科学。免疫抑制的药物基因组学是针对需要免疫抑制的特定免疫介导的临床实体量身定制特定免疫抑制药物疗法的组合技术，该药物可与个体的基因组组成进行最佳匹配。药物基因组学在临床免疫抑制中的及时，明智的应用应指导临床医生针对任何给定的临床状况选择最佳的免疫抑制药物，并显着提高其疗效以及减少副作用和毒性的发生率，从而降低发病率并延长生存期。这是对免疫抑制中正在进行的临床进化的描述还是对未来事件的预测？免疫抑制的药物基因组学的希望很高，但是这种高度专业化的临床科学的希望的可用性和/或应用和/或实现却非常缓慢。

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