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The changing field of vaccine development in the genomics era.

机译:基因组学时代疫苗开发领域的变化。

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摘要

An improved understanding of the human immune system and the genetic make-up of pathogens, together with advances in instrumentation and bioinformatics, have provided new insights into the variation of immune responses to vaccines within the human population. Pathogen variation and the diversity of the immune system components within the human population make the design of universal vaccines difficult. New subunit vaccines that target immunologically similar subgroups of the human population and representative pathogen variants are emerging from research that combines immunomics, pathogen genomics, and high-throughput instrumentation.
机译:对人类免疫系统和病原体遗传构成的更好理解,以及仪器和生物信息学的进步,为人们对疫苗免疫反应的变化提供了新见解。人群中的病原体变异和免疫系统成分的多样性使通用疫苗的设计变得困难。结合免疫组学,病原体基因组学和高通量仪器的研究不断涌现,新的针对人类免疫学相似亚组和代表性病原体变体的亚单位疫苗。

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