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首页> 外文期刊>Pharmacogenomics >Cancer pharmacogenomics: do cancer cell lines have the right stuff?
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Cancer pharmacogenomics: do cancer cell lines have the right stuff?

机译：癌症药物基因组学：癌细胞系是否有合适的原料？

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摘要

In order to improve cancer patient outcomes, considerable effort has been undertaken to identify genomic alterations that impact patient response to chemotherapy. Once all the relevant alterations become known, it is hoped that the promise of individualized therapy, where each patient is treated with the optimal chemotherapy regimen for their tumor, would become fulfilled. Since clinical tissues are limited both in quantity and availability, many researchers have used cancer cell lines in their pharmacogenomics research. Cancer cell lines serve as useful models for clinical tumors because they proliferate readily, are experimentally tractable and are a renewable resource. One such resource in pharmacogenomics research is the NCI60 panel, a panel of 60 different cell lines encompassing nine different types of cancer (reviewed in [1]). The NCI60 panel has been utilized in studies to screen compounds for cytotoxic activity and potential clinical targets, while also identifying the necessary molecular factors required for cytotoxic activity. But with all the effort and money being put into pharmacogenomics research using cancer cell lines, it is appropriate to ask: how faithfully do cancer cell lines represent the tumors that they are being used to model?
机译：为了改善癌症患者的预后，已经进行了相当大的努力来确定影响患者对化学疗法反应的基因组改变。一旦了解了所有相关的变化，就有望实现个性化治疗的承诺，即对每个患者进行针对其肿瘤的最佳化疗方案的治疗。由于临床组织的数量和可用性都受到限制，因此许多研究人员在其药物基因组学研究中使用了癌细胞系。癌细胞系可以很容易地增殖，在实验上容易处理并且是可再生资源，因此可以用作临床肿瘤的有用模型。药物基因组学研究中的此类资源之一是NCI60小组，该小组由60种不同的细胞系组成，涵盖9种不同类型的癌症（在[1]中进行了综述）。 NCI60小组已用于研究中，以筛选化合物的细胞毒活性和潜在的临床靶标，同时还鉴定出细胞毒活性所需的必要分子因子。但是，在使用癌细胞系进行药物基因组学研究的过程中，投入了所有的精力和金钱，应该问一个问题：癌细胞系如何忠实地代表他们正在建模的肿瘤？

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